Linné T, Rundgren M
Acta Physiol Scand. 1986 Jan;126(1):45-9. doi: 10.1111/j.1748-1716.1986.tb07787.x.
The urinary excretion of arginine vasopressin (AVP) was studied during volume expansion (VE) in nine healthy normotensive individuals and 14 patients with active IgA glomerulonephritis (GN). The studies were started after 17-18 h of food and fluid deprivation (hydropenia, HP) and VE was induced by a continuous infusion of Ringer solution up to an amount corresponding to 3% of the body weight. The clearance of inulin and PAH, urine osmolality and urinary excretion of sodium and AVP were determined. The AVP excretion decreased in response to VE in the healthy individuals, both when related to GFR (from 129 +/- 17 pg min-1 100 ml-1 GFR during HP to 65 +/- 9 after 3% VE, P less than 0.01) and to body surface area (BSA) (from 134 +/- 22 pg min-1 1.73 m-2 BSA to 75 +/- 11, P less than 0.05). In the patients with IgA GN, who had normal blood pressure and normal GFR, the AVP excretion tended to decrease, but the change was not significant (0.05 less than P less than 0.1). The patients with hypertension but essentially normal GFR, and those with hypertension and markedly decreased GFR did not change their renal excretion of AVP in response to VE. If related to the GFR, the latter patients had a markedly increased AVP excretion.
在9名健康血压正常个体和14名活动性IgA肾小球肾炎（GN）患者中，研究了容量扩张（VE）期间精氨酸加压素（AVP）的尿排泄情况。研究在禁食禁水17 - 18小时（缺水，HP）后开始，通过持续输注林格溶液诱导VE，直至输入量相当于体重的3%。测定了菊粉和对氨基马尿酸清除率、尿渗透压以及钠和AVP的尿排泄量。在健康个体中，与肾小球滤过率（GFR）相关时（从HP期间的129±17 pg min⁻¹ 100 ml⁻¹ GFR降至3% VE后的65±9，P＜0.01）以及与体表面积（BSA）相关时（从134±22 pg min⁻¹ 1.73 m⁻² BSA降至75±11，P＜0.05），AVP排泄量均随VE而降低。在血压正常且GFR正常的IgA GN患者中，AVP排泄量有降低趋势，但变化不显著（0.05＜P＜0.1）。高血压但GFR基本正常的患者以及高血压且GFR显著降低的患者，其肾脏对AVP的排泄量在VE时无变化。与GFR相关时，后一组患者的AVP排泄量显著增加。
