Bald M, Rascher W, Schärer K
Division of Pediatric Nephrology, Children's Hospital, University of Heidelberg, FRG.
Child Nephrol Urol. 1988;9(5):259-63.
Plasma concentration and urinary excretion of arginine vasopressin (AVP) were measured in 20 children and adolescents with normal or moderately impaired renal function. Plasma AVP was higher in children with an inulin clearance less than 60 ml/min X 1.73 m2, whereas plasma osmolality did not differ in all children. Urinary excretion and urinary clearance of AVP (UCAVP) decreased in relation to impairment of renal function, and a strong negative correlation was found between plasma AVP and log UCAVP. Reduced urinary excretion of AVP may contribute to elevated plasma AVP in children with impaired renal function.
对20名肾功能正常或轻度受损的儿童及青少年测定了精氨酸加压素（AVP）的血浆浓度及尿排泄量。菊粉清除率低于60 ml/min×1.73 m2的儿童血浆AVP较高，而所有儿童的血浆渗透压并无差异。AVP的尿排泄量及尿清除率（UCAVP）随肾功能损害而降低，且血浆AVP与log UCAVP之间存在强负相关。肾功能受损儿童中，AVP尿排泄量减少可能导致血浆AVP升高。
