Stanford J L, Rook G A, Bahr G M, Dowlati Y, Ganapati R, Ghazi Saidi K, Lucas S, Ramu G, Torres P, Minh Ly H
Department of Medical Microbiology, School of Pathology, University College and Middlesex School of Medicine, London, UK.
Vaccine. 1990 Dec;8(6):525-30. doi: 10.1016/0264-410x(90)90002-4.
Both leprosy and tuberculosis present continuing problems in their control, especially in the developing world, despite the availability of drugs effective in producing a bacteriological cure. Improved immunoprophylaxis, and an effective immunotherapy to be used with chemotherapy are urgently required. Intradermal injection of a suspension of killed Mycobacterium vaccae promotes cell-mediated responses to antigens common to all mycobacteria, and switches off the tissue-necrotizing aspects of the Koch phenomenon. These properties led to the use of the suspensions as an improved vaccine, either alone or in combination with BCG. The same properties led to the employment of the suspension in immunotherapy as an adjunct to chemotherapy in the treatment of both leprosy and tuberculosis. The evidence leading to these conclusions is reviewed and discussed.
尽管有能实现细菌学治愈的有效药物，但麻风病和结核病的防控仍面临持续挑战，尤其是在发展中世界。迫切需要改进免疫预防措施以及可与化疗联合使用的有效免疫疗法。皮内注射灭活的母牛分枝杆菌悬液可促进针对所有分枝杆菌共有的抗原的细胞介导反应，并抑制科赫现象的组织坏死方面。这些特性使得该悬液被用作一种改良疫苗，单独使用或与卡介苗联合使用。同样的特性也促使该悬液被用于免疫治疗，作为麻风病和结核病化疗的辅助手段。本文对得出这些结论的证据进行了综述和讨论。
