Gyasi Agyemang Eugene, Confederat Samuel, Mohanan Gayathri, Azimzadeh Sani Mahnaz, Chau Chalmers, Charnock Dylan, Wälti Christoph, Tschulik Kristina, Edwards Martin Andrew, Actis Paolo
Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, 72701, USA.
Materials Science and Engineering, University of Arkansas, Fayetteville, AR, 72701, USA.
Faraday Discuss. 2025 Feb 17;257(0):303-315. doi: 10.1039/d4fd00143e.
Nanopores are emerging as a powerful tool for the analysis and characterization of nanoparticles at the single entity level. Here, we report that a PEG-based polymer electrolyte present inside the nanopore enables the enhanced detection of nanoparticles at low ionic strength. We develop a numerical model that recapitulates the electrical response of the glass nanopore system, revealing the response to be sensitive to the position of the polymer electrolyte interface. As proof of concept, we demonstrate the multimodal analysis of a nanoparticle sample by coupling the polymer electrolyte nanopore sensor with nanoimpact electrochemistry. This combination of techniques could deliver the multiparametric analysis of nanoparticle systems complementing electrochemical reactivity data provided by nanoimpact electrochemistry with information on size, shape and surface charge provided by nanopore measurements.
纳米孔正逐渐成为在单实体水平上分析和表征纳米颗粒的强大工具。在此，我们报告称，纳米孔内部存在的基于聚乙二醇的聚合物电解质能够在低离子强度下增强对纳米颗粒的检测。我们开发了一个数值模型，该模型概括了玻璃纳米孔系统的电响应，揭示了该响应对聚合物电解质界面位置敏感。作为概念验证，我们通过将聚合物电解质纳米孔传感器与纳米冲击电化学相结合，展示了对纳米颗粒样品的多模态分析。这种技术组合可以实现纳米颗粒系统的多参数分析，用纳米孔测量提供的尺寸、形状和表面电荷信息补充纳米冲击电化学提供的电化学反应性数据。
