Shellhart W C, Casamassimo P S, Hagerman R J, Belanger G K
Am J Med Genet. 1986 Jan-Feb;23(1-2):179-87. doi: 10.1002/ajmg.1320230112.
This study compares the oral findings in fragile X syndrome individuals to those of normal age-matched patients. Sixteen fra(X) males (mean age 22 10/12 years) had a low caries rate (decayed, missing and filled surfaces (DMFS) = 12.3) and minimal intraoral hard or soft tissue disease. Rate of malocclusion, as determined by the first permanent molar classification of Angle, was not significantly different from that of matched subjects. Fra(X) subjects had a significantly higher occurrence of malocclusion as compared to matched subjects using crossbite and openbite as criteria. Palatal dimensions of fra(X) subjects did not differ significantly from those of the matched sample. The fra(X) males also demonstrated significantly more severe occlusal wear of their teeth than the matched sample.
本研究将脆性X综合征个体的口腔检查结果与年龄匹配的正常患者进行比较。16名脆性X综合征男性（平均年龄22又10/12岁）的龋齿率较低（龋失补牙面数（DMFS）=12.3），口腔内硬组织或软组织疾病极少。根据安氏第一恒磨牙分类法确定的错颌畸形发生率与匹配对象无显著差异。以反合和开合为标准，脆性X综合征患者的错颌畸形发生率显著高于匹配对象。脆性X综合征患者的腭部尺寸与匹配样本无显著差异。脆性X综合征男性的牙齿咬合磨损也明显比匹配样本更严重。
