Wang Xiaochuan, Cui Hong, Li Na, Liu Borui, Zhang Xiaoyan, Yang Jing, Zheng Ju-Sheng, Qiao Chong, Liu Hui-Xin, Hu Jiajin, Wen Deliang
Research Center of China Medical University Birth Cohort, China Medical University, Shenyang 110122, China; Health Sciences Institute, China Medical University, Shenyang 110122, China; Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, Shenyang 110122, China.
Research Center of China Medical University Birth Cohort, China Medical University, Shenyang 110122, China; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, China Medical University, Shenyang 110004, China.
J Infect. 2024 Dec;89(6):106348. doi: 10.1016/j.jinf.2024.106348. Epub 2024 Nov 12.
This systematic review summarizes eight studies involving 558 cesarean section (CS)-born infants (274 exposed to vaginal seeding (VS), 284 not exposed) and 261 infants born vaginally to investigate the effect of VS on gut microbiome colonization and development in CS-born infants.
This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant articles published before March 6, 2024, were identified through systematic searches of PubMed, Scopus, and Web of Science. We included experimental studies that investigated changes in the gut microbiota of CS-born infants following VS and reported changes in the gut microbiota. The relationship between VS and the gut microbiota composition of CS-born infants was assessed.
VS may selectively influence the abundance of bacterial genera from various phyla, such as an increased relative abundance of Bacteroides and Lactobacillus, in the gut microbiome of CS-seeded infants compared to CS-non-seeded infants. Conflicting results mainly concern microbial diversity.
Current evidence indicates modest changes in the gut microbiome of CS-born infants following VS. However, further clinical studies are necessary to fully understand its impact on early-life health outcomes, particularly regarding potential microbiome alterations and associated health risks.
本系统评价总结了八项研究，涉及558名剖宫产出生的婴儿（274名接受阴道播种（VS），284名未接受）以及261名经阴道出生的婴儿，以调查VS对剖宫产出生婴儿肠道微生物群定植和发育的影响。
本研究遵循系统评价和Meta分析的首选报告项目指南。通过对PubMed、Scopus和Web of Science进行系统检索，确定了2024年3月6日前发表的相关文章。我们纳入了调查VS后剖宫产出生婴儿肠道微生物群变化并报告肠道微生物群变化的实验研究。评估了VS与剖宫产出生婴儿肠道微生物群组成之间的关系。
与未接受VS的剖宫产婴儿相比，VS可能会选择性地影响剖宫产接种婴儿肠道微生物群中来自不同门的细菌属的丰度，例如拟杆菌属和乳杆菌属的相对丰度增加。相互矛盾的结果主要涉及微生物多样性。
目前的证据表明，VS后剖宫产出生婴儿的肠道微生物群有适度变化。然而，需要进一步的临床研究来充分了解其对早期健康结局的影响，特别是关于潜在的微生物群改变和相关健康风险。
