Srinivasjois Ravisha, Rao Shripada, Pereira Gavin
Department of Neonatology and Paediatrics, Joondalup Health Campus, Perth, WA 6027, Australia.
Medical School, University of Western Australia, Perth, WA 6005, Australia.
Microorganisms. 2025 Jul 29;13(8):1772. doi: 10.3390/microorganisms13081772.
The first few days following the birth are a vulnerable time for the neonate. Sick infants experience various interventions during their stay in the neonatal unit in order to stay alive and grow. Acquisition of gut microbes is critical for the short- and long-term health of the neonate. At a time when the gut microbiome is starting to take shape, crucial interventions directed at improving the growth, development and survival of the neonate impact its development. Events prior to and after the birth of the neonate, such as maternal conditions, antibiotic exposure, type of feeds, supplemental probiotics, and neonatal intensive care environment, contribute significantly to shaping the gut microbiome over the first few weeks and maintain its healthy balance crucial for long-term health. In this comprehensive review, we address common interventions the neonate is exposed to in its journey and their impact on gut microbiome, and discuss various interventions that minimize the dysbiosis of the gut.
出生后的头几天对新生儿来说是脆弱期。患病婴儿在新生儿病房期间会接受各种干预措施以维持生命并成长。肠道微生物的获取对新生儿的短期和长期健康至关重要。在肠道微生物群开始形成之际，旨在改善新生儿生长、发育和生存的关键干预措施会影响其发育。新生儿出生前后的事件，如母亲的状况、抗生素暴露、喂养类型、补充益生菌以及新生儿重症监护环境等，在最初几周对塑造肠道微生物群有显著作用，并维持对长期健康至关重要的健康平衡。在这篇综述中，我们阐述了新生儿在成长过程中所接触到的常见干预措施及其对肠道微生物群的影响，并讨论了各种可将肠道生态失调降至最低的干预措施。
