Han Yong-He, Cui Xi-Wen, Li Yi-Xi, Chen Xian, Zhang Hong, Zhang Yong, Wang Shan-Shan, Li Min
Fujian Key Laboratory of Pollution Control and Resource Reuse, College of Environmental and Resource Sciences, Fujian Normal University, Fuzhou 350117, China.
Fujian Key Laboratory of Pollution Control and Resource Reuse, College of Environmental and Resource Sciences, Fujian Normal University, Fuzhou 350117, China.
Int J Biol Macromol. 2024 Dec;283(Pt 1):137522. doi: 10.1016/j.ijbiomac.2024.137522. Epub 2024 Nov 12.
Obesity has attracted great concern because of its undesirable effects on our life quality. Bacterial cellulose (BC) is a biological macromolecule that can improve gut homeostasis and lipid metabolism. However, its potential role in preventing obesity and associated mechanisms is still poorly understood. Herein, a supplement of BC was used to fully evaluate how it prevents obesity based on physio-biochemical and gut microbial analyses. Results showed that BC consumption helped decrease body and liver weight, and fat accumulation in kidney and epididymis. Correspondingly, glucose concentrations, total triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were reversed to the control levels. Consuming BC also improved liver fat metabolism and intestinal function, and alleviated ileum and epididymis inflammation. High-throughput sequencing suggested that a high-fat diet significantly decreased gut microbiota diversity, which could be reversed by consuming BC. A decreased Firmicutes and Proteobacteria and an increased Bacteroidetes following BC consumption were observed. The OTU-based analysis identified that Lachnospiraceae, Desulfovibrio, Lachnoclostridium, Blautia, Anaerotruncus, Bacteroides, Faecalibaculum, Bacteroidales S24-7 group, Prevotellaceae UCG-001 group, and Alloprevotella might be involved in obesity development or prevention. Our data suggest that BC is a good insoluble dietary fiber to prevent obesity via regulating lipid metabolism and gut microbiota.
肥胖因其对我们生活质量的不良影响而备受关注。细菌纤维素（BC）是一种生物大分子，可改善肠道内环境稳定和脂质代谢。然而，其在预防肥胖方面的潜在作用及相关机制仍知之甚少。在此，通过生理生化和肠道微生物分析，使用BC补充剂全面评估其预防肥胖的方式。结果表明，食用BC有助于降低体重和肝脏重量，以及肾脏和附睾中的脂肪堆积。相应地，血糖浓度、总甘油三酯、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇恢复到对照水平。食用BC还改善了肝脏脂肪代谢和肠道功能，并减轻了回肠和附睾炎症。高通量测序表明，高脂饮食显著降低了肠道微生物群的多样性，而食用BC可使其逆转。观察到食用BC后厚壁菌门和变形菌门减少，拟杆菌门增加。基于OTU的分析确定，毛螺菌科、脱硫弧菌属、拉克诺梭菌属、布劳特氏菌属、厌氧短杆菌属、拟杆菌属、粪杆菌属、拟杆菌目S24-7组、普雷沃氏菌科UCG-001组和别普雷沃氏菌属可能参与肥胖的发生或预防。我们的数据表明，BC是一种良好的不溶性膳食纤维，可通过调节脂质代谢和肠道微生物群来预防肥胖。
