Wang Anyun, Liu Xinli, Feng Shujun, Wang Yanping, Song Yujun, Gao Yanfeng
School of Public Health, Wannan Medical College, Wuhu, 241002, China.
Life Sciences Institute, Guangxi Medical University, Nanning, 530021, China.
Chembiochem. 2025 Feb 3;26(5):e202400807. doi: 10.1002/cbic.202400807. Epub 2024 Nov 28.
Covalent organic frameworks (COFs) have emerged as a distinguished class of porous materials. Owing to their ability to be constructed through covalent bonds involving light elements, such as hydrogen, boron, carbon, nitrogen, and oxygen, COFs offer greater stability and lower cytotoxicity than metal-organic frameworks do, addressing critical limitations in in vivo applications. Their unique attributes, such as high surface area, customizable pore sizes, and versatile surface functionalities, make them ideal for various biomedical applications. This review aims to provide an overview of the recent advancements in modern COFs for biomedical uses. First, a variety of methods for the synthesis of COFs are outlined, which ensures their suitability for medical use. Next, we delve into innovative biomedical applications, emphasizing their roles in disease diagnosis and therapies. Finally, challenges, such as clinical translation, biocompatibility, and controlled drug release, are critically discussed, providing comprehensive insight into the potential of COFs in revolutionizing biomedical technologies. Overall, this review offers a comprehensive overview of COFs' capabilities and future prospects in enhancing biomedical technologies.
共价有机框架（COFs）已成为一类杰出的多孔材料。由于它们能够通过涉及氢、硼、碳、氮和氧等轻元素的共价键构建而成，与金属有机框架相比，COFs具有更高的稳定性和更低的细胞毒性，解决了体内应用中的关键限制。它们独特的属性，如高比表面积、可定制的孔径和多样的表面功能，使其成为各种生物医学应用的理想选择。本综述旨在概述现代COFs在生物医学用途方面的最新进展。首先，概述了多种合成COFs的方法，以确保它们适用于医学用途。接下来，我们深入探讨创新的生物医学应用，强调它们在疾病诊断和治疗中的作用。最后，对临床转化、生物相容性和药物控释等挑战进行了批判性讨论，全面洞察了COFs在革新生物医学技术方面的潜力。总体而言，本综述全面概述了COFs在增强生物医学技术方面的能力和未来前景。
