He Xuelu, Jiang Zhenqi, Akakuru Ozioma Udochukwu, Li Juan, Wu Aiguo
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P. R. China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Chem Commun (Camb). 2021 Nov 23;57(93):12417-12435. doi: 10.1039/d1cc04846e.
Covalent organic frameworks (COFs), as a new type of crystalline porous materials, mainly consist of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds to form periodical structures of two or three dimensions. As an attribute of their low density, large surface area, and excellent adjustable pore size, COFs show great potential in many fields including energy storage and separation, catalysis, sensing, and biomedicine. However, compared with metal organic frameworks (MOFs), the relatively large size and irregular morphology of COFs affect their biocompatibility and bioavailability , thus impeding their further biomedical applications. This Review focuses on the controlled design strategies of nanoscale COFs (NCOFs), unique properties of NCOFs for biomedical applications, and recent progress in NCOFs for cancer therapy. In addition, current challenges for the biomedical use of NCOFs and perspectives for further improvements are presented.
共价有机框架材料（COFs）作为一种新型的晶体多孔材料，主要由通过动态共价键连接的轻质元素（H、B、C、N和O）组成，形成二维或三维的周期性结构。由于其低密度、大表面积和优异的孔径可调性等特性，COFs在储能与分离、催化、传感和生物医学等许多领域都展现出巨大潜力。然而，与金属有机框架材料（MOFs）相比，COFs相对较大的尺寸和不规则的形态影响了它们的生物相容性和生物利用度，从而阻碍了它们在生物医学领域的进一步应用。本综述重点关注纳米级COFs（NCOFs）的可控设计策略、NCOFs在生物医学应用中的独特性质以及NCOFs用于癌症治疗的最新进展。此外，还介绍了NCOFs在生物医学应用方面当前面临的挑战以及进一步改进的前景。
