Qiao Zheng-Bo, Gu Ming-Zhong, Wang Yu-Wu, Ma Bin-Bin, Pang Shan-Shan
Department of Emergency Medicine, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People's Hospital, Yancheng 224000, China.
Department of Orthopedics, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People's Hospital, Yancheng 224000, China.
Bone Rep. 2024 Jul 15;22:101790. doi: 10.1016/j.bonr.2024.101790. eCollection 2024 Sep.
Current research has demonstrated that Simvastatin (SIM) and Whole Body Vibration (WBV) actively contributes to the repair of osteoporotic bones. However, there is still limited knowledge regarding the impact of this combined therapy on osseointegration in elderly individuals. Objective: The objective of this study was to verify the influence of WBV and SIM combination treatment on Titanium implants' fixation strength in aged rats.
Male Sprague-Dawley rats at 24 months old were utilized for this investigation. Titanium rods were surgically inserted into the distal femoral canal on their left side. Subsequently, all animals were randomly assigned to one of four groups: Control group; WBV group; SIM group; and WBV + SIM group. Each group received Saline, Whole Body Vibration, Simvastatin, or a combination of Whole Body Vibration plus Simvastatin treatment until they reached their natural death after 12 weeks. The bilateral femurs and serum samples from these rats were collected for evaluation purposes.
Both WBV and SIM treatments exhibited an increase in bone mass, osseointegration, and push-out force compared to the Control group (all, < 0.05). Additionally, levels of oxidative stress and inflammatory factors decreased with both treatments when compared to the Control group alone (all, < 0.05). Notably, the WBV + SIM group displayed superior effects on new bone formation, biomechanical strength, BMP2 expression in bone tissue as well as SOD2 expression regulation related to bone repair genes when compared to other groups involved in this study (all, < 0.05).
These findings suggest that combining physiotherapy (WBV) with drug therapy (SIM) proves beneficial for enhancing implant fixation in aged rats.
目前的研究表明，辛伐他汀（SIM）和全身振动（WBV）对骨质疏松性骨的修复有积极作用。然而，关于这种联合治疗对老年人骨整合的影响，目前的了解仍然有限。目的：本研究的目的是验证WBV和SIM联合治疗对老年大鼠钛植入物固定强度的影响。
本研究使用24个月大的雄性Sprague-Dawley大鼠。通过手术将钛棒插入其左侧股骨干远端髓腔内。随后，所有动物被随机分为四组之一：对照组；WBV组；SIM组；WBV + SIM组。每组分别接受生理盐水、全身振动、辛伐他汀或全身振动加辛伐他汀联合治疗，直至12周后自然死亡。收集这些大鼠的双侧股骨和血清样本用于评估。
与对照组相比，WBV和SIM治疗均使骨量、骨整合和推出力增加（均P < 0.05）。此外，与单独的对照组相比，两种治疗均使氧化应激和炎症因子水平降低（均P < 0.05）。值得注意的是，与本研究中的其他组相比，WBV + SIM组在新骨形成、生物力学强度、骨组织中BMP2表达以及与骨修复基因相关的SOD2表达调节方面显示出更优的效果（均P < 0.05）。
这些发现表明，物理治疗（WBV）与药物治疗（SIM）相结合对增强老年大鼠的植入物固定有益。
