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Neuronal Excitability in Trisomy 21-Up or ?

作者信息

Stafstrom Carl E

机构信息

Division of Pediatric Neurology Johns Hopkins University School of Medicine.

出版信息

Epilepsy Curr. 2024 Oct 16;24(6):440-442. doi: 10.1177/15357597241285779. eCollection 2024 Nov-Dec.

DOI:10.1177/15357597241285779
PMID:39540135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11556655/
Abstract
摘要

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iScience. 2024 Mar 8;27(4):109438. doi: 10.1016/j.isci.2024.109438. eCollection 2024 Apr 19.
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Increased propensity for infantile spasms and altered neocortical excitation-inhibition balance in a mouse model of down syndrome carrying human chromosome 21.唐氏综合征小鼠模型中人 21 号染色体导致婴儿痉挛倾向增加和新皮层兴奋抑制平衡改变。
Neurobiol Dis. 2023 Aug;184:106198. doi: 10.1016/j.nbd.2023.106198. Epub 2023 Jun 13.
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The Impact of Mmu17 Non-Hsa21 Orthologous Genes in the Ts65Dn Mouse Model of Down Syndrome: The Gold Standard Refuted.Mmu17 非 Hsa21 同源基因在唐氏综合征 Ts65Dn 小鼠模型中的作用：金标准被推翻。
Biol Psychiatry. 2023 Jul 1;94(1):84-97. doi: 10.1016/j.biopsych.2023.02.012. Epub 2023 Mar 14.
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Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome.使用抗 NKCC1 基因治疗恢复神经元氯离子稳态可挽救唐氏综合征小鼠模型的认知缺陷。
Mol Ther. 2021 Oct 6;29(10):3072-3092. doi: 10.1016/j.ymthe.2021.05.023. Epub 2021 May 29.
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Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome.在唐氏综合征的主要小鼠模型中，地西泮的非典型电生理和行为反应。
Sci Rep. 2021 May 4;11(1):9521. doi: 10.1038/s41598-021-89011-y.
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Cerebal overinhibition could be the basis for the high prevalence of epilepsy in persons with Down syndrome.大脑过度抑制可能是唐氏综合征患者癫痫高发的原因。
Epilepsy Behav. 2015 Dec;53:120-5. doi: 10.1016/j.yebeh.2015.10.004. Epub 2015 Nov 8.
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Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.逆转兴奋性 GABAAR 信号可恢复唐氏综合征小鼠模型的突触可塑性和记忆。
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Epilepsy in children with Down syndrome.唐氏综合征儿童的癫痫。
Epileptic Disord. 2011 Mar;13(1):1-7. doi: 10.1684/epd.2011.0415.
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