Zouki Dionysia N, Karatrasoglou Eleni A, Pilichos Georgios, Papadimitraki Elisavet
Breast Unit, University College London Hospitals NHS Foundation Trust, London, UK.
Department of Surgery, Karlstad Central Hospital, Rosenborgsgatan 9, 65230, Karlstad, Sweden.
Curr Treat Options Oncol. 2024 Dec;25(12):1482-1494. doi: 10.1007/s11864-024-01275-4. Epub 2024 Nov 14.
Breast cancer represents one of the most common malignancies worldwide. In early stages a combination of treatment strategies are offered with curative intent, whereas the therapeutic aim in metastatic disease is to provide the longest possible survival with an acceptable quality of life. The term "oligometastasis", first described by Hellmann and Weichselbaum in 1995, represents an intermediate state between local and systemic disease, where radical focal treatments to all metastatic lesions might have a curative potential. Due to sufficient lack of data, the proper management of oligometastatic disease remains even until today a highly unmet need. Surgery, radiotherapy or ablation (radiofrequency or cryotherapy) are among the local eradication therapies that could offer long-term outcomes in patients with oligometastatic breast cancer (OMBC). The present review aims to bring the readers up to the latest data regarding the management of OMBC according to the different organs involved by setting a framework of current treatment paradigms. It also brings to the forefront debatable questions requiring multidisciplinary approach and highlights the concerns arising from dealing with this clinically and biologically unique entity in everyday clinical practice.
乳腺癌是全球最常见的恶性肿瘤之一。在早期阶段，会采用多种治疗策略以达到治愈目的，而转移性疾病的治疗目标是在可接受的生活质量前提下实现尽可能长的生存期。“寡转移”一词由赫尔曼和魏克塞尔鲍姆于1995年首次提出，它代表了局部和全身性疾病之间的一种中间状态，对所有转移病灶进行根治性局部治疗可能具有治愈潜力。由于数据严重不足，直至今日，寡转移性疾病的合理管理仍是一个亟待满足的巨大需求。手术、放疗或消融（射频或冷冻治疗）属于局部根除疗法，这些疗法可为寡转移性乳腺癌（OMBC）患者带来长期疗效。本综述旨在通过建立当前治疗模式的框架，让读者了解有关根据不同受累器官对OMBC进行管理的最新数据。它还提出了需要多学科方法解决的有争议问题，并强调了在日常临床实践中处理这一临床和生物学上独特实体时所产生的问题。
