肝转移乳腺癌：流行病学、饮食干预及相关代谢。

Liver Metastatic Breast Cancer: Epidemiology, Dietary Interventions, and Related Metabolism.

机构信息

Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Department of Neuroscience, Northwestern University, Evanston, IL 60208, USA.

出版信息

Nutrients. 2022 Jun 8;14(12):2376. doi: 10.3390/nu14122376.

DOI:10.3390/nu14122376

PMID:35745105

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9228756/

Abstract

The median overall survival of patients with metastatic breast cancer is only 2-3 years, and for patients with untreated liver metastasis, it is as short as 4-8 months. Improving the survival of women with breast cancer requires more effective anti-cancer strategies, especially for metastatic disease. Nutrients can influence tumor microenvironments, and cancer metabolism can be manipulated via a dietary modification to enhance anti-cancer strategies. Yet, there are no standard evidence-based recommendations for diet therapies before or during cancer treatment, and few studies provide definitive data that certain diets can mediate tumor progression or therapeutic effectiveness in human cancer. This review focuses on metastatic breast cancer, in particular liver metastatic forms, and recent studies on the impact of diets on disease progression and treatment.

摘要

转移性乳腺癌患者的中位总生存期仅为 2-3 年，而未经治疗的肝转移患者的生存期更短，仅有 4-8 个月。提高乳腺癌患者的生存率需要更有效的抗癌策略，特别是针对转移性疾病。营养物质可以影响肿瘤微环境，并且可以通过饮食改变来操纵癌症代谢，以增强抗癌策略。然而，在癌症治疗之前或期间，没有针对饮食疗法的标准循证建议，并且很少有研究提供明确的数据表明某些饮食可以调节人类癌症中的肿瘤进展或治疗效果。本综述重点关注转移性乳腺癌，特别是肝转移形式，以及最近关于饮食对疾病进展和治疗影响的研究。