Okafor L A, Obi J O
Angiology. 1986 Feb;37(2):75-8. doi: 10.1177/000331978603700201.
The extent of tissue damage caused by vaso-occlusion in sickle cell disease in those organs rich in acid phosphatase was assessed by measuring serum acid phosphatase in 33 patients with homozygous sickle cell disease Hb-SS (sicklers) and comparing the result with that of 31 persons with normal haemoglobin-AA (non-sicklers) matched for age and sex. The result showed a decrease in the level of total, labile and tartrate-resistant serum acid phosphatase in sicklers compared to non-sicklers, though the decrease is not statistically significant (p greater than 0.1). Though serum acid phosphatase is unlikely to be a useful index for the assessment of organ damage, the result is in consonance with reported decreases in other body secretions such as serum testosterone or aldosterone due to organ damage by vaso-occlusion of the micro-circulation by sickled red cells in sickle cell disease.
通过检测33例纯合子镰状细胞病Hb-SS患者（镰状细胞贫血患者）的血清酸性磷酸酶，并将结果与31例年龄和性别匹配的正常血红蛋白AA者（非镰状细胞贫血患者）进行比较，评估了镰状细胞病中富含酸性磷酸酶的器官因血管阻塞所导致的组织损伤程度。结果显示，与非镰状细胞贫血患者相比，镰状细胞贫血患者的总血清酸性磷酸酶、不稳定血清酸性磷酸酶和抗酒石酸血清酸性磷酸酶水平有所下降，尽管这种下降在统计学上并不显著（p大于0.1）。虽然血清酸性磷酸酶不太可能作为评估器官损伤的有用指标，但该结果与报道的镰状细胞病中镰状红细胞对微循环的血管阻塞导致器官损伤，进而使血清睾酮或醛固酮等其他身体分泌物减少的情况一致。
