Okafor L A, Nonnoo D C, Ojehanon P I, Aikhionbare O
Angiology. 1986 Sep;37(9):672-5. doi: 10.1177/000331978603700909.
A clinical evaluation of the oral and dental complications of sickle cell disease in Nigerians was carried out in 37 consecutive patients with homozygous sickle cell disease Hb-SS (Sicklers) compared to a control group of 24 persons with normal haemoglobin Hb-AA (control group) matched for age and sex. The significant abnormalities found in sicklers included intrinsic opacity of the teeth in 67.5% of sicklers compared to 28.83% in the control group; malocclusion of the teeth with over-jet and over-bite in 35% of sicklers compared to 16.66% in the control group; dental caries is present in 35.13% of sicklers which was less than its occurrence in 54% of the control group due to widespread avoidance of sweets by most local sicklers. Diastemata (gaps between the teeth) was present in approximately equal frequency in sicklers (27%) and control group (25%). In view of the aesthetic and medical implications of these abnormalities, it is recommended that sicklers should receive regular dental check-up with a view to ameliorating or preventing these complications by prophylactic measures including the use of orthodontic appliances such as braces, etc. The above findings are discussed in relation to the other complications of sickler cell disease in other organs of the body.
对37例纯合子镰状细胞病Hb-SS患者（镰状细胞贫血患者）的口腔和牙齿并发症进行了临床评估，并与24名年龄和性别匹配的血红蛋白正常的Hb-AA对照组（对照组）进行了比较。镰状细胞贫血患者中发现的显著异常包括：67.5%的镰状细胞贫血患者牙齿出现内源性浑浊，而对照组为28.83%；35%的镰状细胞贫血患者牙齿错合伴覆盖和覆合，而对照组为16.66%；35.13%的镰状细胞贫血患者有龋齿，由于大多数当地镰状细胞贫血患者普遍避免食用甜食，其龋齿发生率低于对照组的54%。牙缝（牙齿间的间隙）在镰状细胞贫血患者（27%）和对照组（25%）中的出现频率大致相同。鉴于这些异常对美观和医学的影响，建议镰状细胞贫血患者应定期进行牙齿检查，以便通过包括使用牙套等正畸器械在内的预防措施来改善或预防这些并发症。上述发现与镰状细胞病在身体其他器官的其他并发症相关进行了讨论。
