Holt-Gosselin Bailey, Keding Taylor J, Poulin Rhayna, Brieant Alexis, Rueter Amanda, Hendrickson Timothy J, Perrone Anders, Byington Nora, Houghton Audrey, Miranda-Dominguez Oscar, Feczko Eric, Fair Damien A, Joormann Jutta, Gee Dylan G
Department of Psychology, Yale University, New Haven, Connecticut; Interdepartmental Neuroscience Graduate Program, Yale University School of Medicine, New Haven, Connecticut.
Department of Psychology, Yale University, New Haven, Connecticut; Child Study Center, Yale School of Medicine, New Haven, Connecticut.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Feb;9(2):185-195. doi: 10.1016/j.bpsc.2023.05.001. Epub 2023 May 12.
Family history of depression is a robust predictor of early-onset depression, which may confer risk through alterations in neural circuits that have been implicated in reward and emotional processing. These alterations may be evident in youths who are at familial risk for depression but who do not currently have depression. However, the identification of robust and replicable findings has been hindered by few studies and small sample sizes. In the current study, we sought to identify functional connectivity (FC) patterns associated with familial risk for depression.
Participants included healthy (i.e., no lifetime psychiatric diagnoses) youths at high familial risk for depression (HR) (n = 754; at least one parent with a history of depression) and healthy youths at low familial risk for psychiatric problems (LR) (n = 1745; no parental history of psychopathology) who were 9 to 10 years of age and from the Adolescent Brain Cognitive Development (ABCD) Study sample. We conducted whole-brain seed-to-voxel analyses to examine group differences in resting-state FC with the amygdala, caudate, nucleus accumbens, and putamen. We hypothesized that HR youths would exhibit global amygdala hyperconnectivity and striatal hypoconnectivity patterns primarily driven by maternal risk.
HR youths exhibited weaker caudate-angular gyrus FC than LR youths (α = 0.04, Cohen's d = 0.17). HR youths with a history of maternal depression specifically exhibited weaker caudate-angular gyrus FC (α = 0.03, Cohen's d = 0.19) as well as weaker caudate-dorsolateral prefrontal cortex FC (α = 0.04, Cohen's d = 0.21) than LR youths.
Weaker striatal connectivity may be related to heightened familial risk for depression, primarily driven by maternal history. Identifying brain-based markers of depression risk in youths can inform approaches to improving early detection, diagnosis, and treatment.
抑郁症家族史是早发性抑郁症的有力预测指标，它可能通过与奖励和情绪处理相关的神经回路改变来增加患病风险。这些改变在有抑郁症家族风险但目前未患抑郁症的青少年中可能很明显。然而，由于研究较少且样本量小，难以确定可靠且可重复的研究结果。在本研究中，我们试图确定与抑郁症家族风险相关的功能连接（FC）模式。
参与者包括来自青少年大脑认知发展（ABCD）研究样本的9至10岁健康（即无终生精神疾病诊断）且有高抑郁症家族风险（HR）的青少年（n = 754；至少一位父母有抑郁症病史）和低精神疾病家族风险（LR）的健康青少年（n = 1745；无父母精神病理学病史）。我们进行了全脑种子点到体素分析，以检查杏仁核、尾状核、伏隔核和壳核静息态FC的组间差异。我们假设HR青少年会表现出主要由母亲风险驱动的整体杏仁核高连接性和纹状体低连接性模式。
HR青少年比LR青少年表现出较弱的尾状核 - 角回FC（α = 0.04，科恩d值 = 0.17）。有母亲抑郁症病史的HR青少年比LR青少年表现出更弱的尾状核 - 角回FC（α = 0.03，科恩d值 = 0.19）以及更弱的尾状核 - 背外侧前额叶皮质FC（α = 0.04，科恩d值 = 0.21）。
较弱的纹状体连接可能与抑郁症家族风险增加有关，主要由母亲病史驱动。识别青少年抑郁症风险的脑标志物可为改善早期检测、诊断和治疗的方法提供信息。
