情绪相关冲动与眶额皮质脑回有关。
Emotion-related impulsivity is related to orbitofrontal cortical sulcation.
机构信息
Department of Psychology, University of California, Berkeley, Berkeley, CA, USA.
Medical Scientist Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
Cortex. 2024 Dec;181:140-154. doi: 10.1016/j.cortex.2024.08.009. Epub 2024 Oct 28.
BACKGROUND
Emotion-related impulsivity (ERI) describes the trait-like tendency toward poor self-control when experiencing strong emotions. ERI has been shown to be elevated across psychiatric disorders and predictive of the onset and worsening of psychiatric syndromes. Recent work has correlated ERI scores with the region-level neuroanatomical properties of the orbitofrontal cortex (OFC), but not posteromedial cortex (PMC). Informed by a growing body of research indicating that examining the morphology of specific cortical folds (sulci) can produce unique insights into behavioral outcomes, the present study modeled the association between ERI and the morphology of sulci within OFC and PMC, which is a finer scale than previously conducted.
METHODS
Analyses were conducted in a transdiagnostic sample of 118 adult individuals with a broad range of psychiatric syndromes. First, we manually defined over 4,000 sulci across 236 cerebral hemispheres. Second, we implemented a model-based LASSO regression to relate OFC sulcal morphology to ERI. Third, we tested whether effects were specific to OFC sulci, sulcal depth, and ERI (as compared to PMC sulci, sulcal gray matter thickness, and non-emotion-related impulsivity).
RESULTS
The LASSO regression revealed bilateral associations of ERI with the depths of eight OFC sulci. These effects were strongest for OFC sulci, sulcal depth, and ERI in comparison to PMC sulci, sulcal gray matter thickness, and non-emotion-related impulsivity. In addition, we identified a new transverse component of the olfactory sulcus in every hemisphere that is dissociable from the longitudinal component based on anatomical features and correlation with behavior, which could serve as a new transdiagnostic biomarker.
CONCLUSIONS
The results of this data-driven investigation provide greater neuroanatomical and neurodevelopmental specificity on how OFC is related to ERI. As such, findings link neuroanatomical characteristics to a trait that is highly predictive of psychopathology.
背景
情绪相关冲动性（ERI）描述了在经历强烈情绪时自我控制能力差的特质倾向。ERI 在各种精神障碍中均升高，并可预测精神综合征的发作和恶化。最近的工作将 ERI 评分与眶额皮层（OFC）的区域水平神经解剖特性相关联，但与后内侧皮层（PMC）无关。越来越多的研究表明，检查特定皮质褶皱（脑沟）的形态可以对行为结果产生独特的见解，受此启发，本研究对 ERI 与 OFC 和 PMC 内脑沟形态之间的关系进行建模，其研究尺度比之前的研究更精细。
方法
在具有广泛精神综合征的 118 名成年个体的跨诊断样本中进行了分析。首先，我们手动定义了 236 个大脑半球中超过 4000 条脑沟。其次，我们实施了基于模型的 LASSO 回归，将 OFC 脑沟形态与 ERI 相关联。第三，我们测试了这些效应是否特定于 OFC 脑沟、脑沟深度和 ERI（与 PMC 脑沟、脑沟灰质厚度和非情绪相关冲动性相比）。
结果
LASSO 回归显示 ERI 与 OFC 的八个脑沟深度呈双侧关联。与 PMC 脑沟、脑沟灰质厚度和非情绪相关冲动性相比，OFC 脑沟、脑沟深度和 ERI 的效应最强。此外，我们在每个半球中都发现了嗅沟的新的横向成分，该成分可根据解剖特征和与行为的相关性与纵向成分区分开来，这可能成为新的跨诊断生物标志物。
结论
这项数据驱动研究的结果提供了关于 OFC 与 ERI 相关的更高神经解剖和神经发育特异性。因此，研究结果将神经解剖特征与高度预测精神病理学的特质联系起来。
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