Groh Janos, Simons Mikael
Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.
Neuron. 2025 Jan 8;113(1):127-139. doi: 10.1016/j.neuron.2024.10.019. Epub 2024 Nov 13.
Aging has a detrimental impact on white matter, resulting in reduced volume, compromised structural integrity of myelinated axons, and an increase in white matter hyperintensities. These changes are closely linked to cognitive decline and neurological disabilities. The deterioration of myelin and its diminished ability to regenerate as we age further contribute to the progression of neurodegenerative disorders. Understanding these changes is crucial for devising effective disease prevention strategies. Here, we will discuss the structural alterations in white matter that occur with aging and examine the cellular and molecular mechanisms driving these aging-related transformations. We highlight how the progressive disruption of white matter may initiate a self-perpetuating cycle of inflammation and neural damage.
衰老对白质有不利影响，导致其体积减小、有髓轴突的结构完整性受损以及白质高信号增加。这些变化与认知衰退和神经功能障碍密切相关。随着年龄增长，髓磷脂的退化及其再生能力的下降进一步促使神经退行性疾病的发展。了解这些变化对于制定有效的疾病预防策略至关重要。在此，我们将讨论衰老过程中白质发生的结构改变，并研究驱动这些与衰老相关转变的细胞和分子机制。我们强调白质的渐进性破坏如何引发炎症和神经损伤的自我持续循环。
