Department of Diabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Department of Diabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Lancet Diabetes Endocrinol. 2024 Dec;12(12):915-923. doi: 10.1016/S2213-8587(24)00243-2. Epub 2024 Nov 11.
Population-based incidence data on young-adult-onset type 1 diabetes and type 2 diabetes are limited. We aimed to examine secular trends in the incidence of diagnosed type 1 diabetes and type 2 diabetes with an age of onset between 15 and 39 years.
In this multicountry aggregate data analysis, we assembled eight administrative datasets from high-income jurisdictions and countries (Australia, Denmark, Finland, Hungary, Japan, Scotland, South Korea, and Spain [Catalonia]) that had appropriate data available from an international diabetes consortium (GLOBODIAB) describing incidence by diabetes type among people aged 15-39 years from 2000 to 2020. We modelled type 1 diabetes and type 2 diabetes incidence rates using Poisson regression including age and calendar time by sex.
During the years 2000-20, there were 349 591 incident diabetes (both types) cases from 346 million person-years of follow-up among people aged 15-39 years. Over time, there was no statistically significant change in the incidence of type 1 diabetes in Hungary and Japan. The incidence of type 1 diabetes significantly increased in Australia, Denmark, Finland, Scotland, South Korea, and Spain, with annual changes ranging from 0·5% to 6·0%. The incidence of type 2 diabetes significantly increased in four of eight jurisdictions (Denmark, Finland, Japan, and South Korea), with annual increases from 2·0% to 8·5%. The magnitude of increase in incidence of type 2 diabetes was greater in Asian than non-Asian jurisdictions. There was no statistically significant change in type 2 diabetes incidence in Australia and Hungary. The incidence of type 2 diabetes significantly decreased in Scotland and Spain, with annual changes of -0·7% and -1·5%, respectively.
There is variability in the trajectory of the incidence of young-adult-onset type 2 diabetes among high-income countries or jurisdictions, with a greater evidence of increase in Asian than non-Asian countries. Evolving trends in the incidence of type 1 and type 2 diabetes in young adults call for the ongoing surveillance of diabetes incidence and a greater research focus on this population.
US Centers for Disease Control and Prevention, Diabetes Australia Research Programme, and Victoria State Government Operational Infrastructure Support Programme.
关于青年发病 1 型和 2 型糖尿病的基于人群的发病率数据有限。本研究旨在调查 15 至 39 岁人群中确诊的 1 型和 2 型糖尿病发病率的长期趋势。
在这项多国家汇总数据分析中，我们从高收入司法管辖区和国家（澳大利亚、丹麦、芬兰、匈牙利、日本、苏格兰、韩国和西班牙[加泰罗尼亚]）的八个行政数据集组装，这些数据集来自一个国际糖尿病联盟（GLOBODIAB），其中包含 2000 年至 2020 年期间年龄在 15 至 39 岁之间的人群中按糖尿病类型描述的发病率数据。我们使用泊松回归模型，包括年龄和按性别划分的日历时间，对 1 型和 2 型糖尿病发病率进行建模。
在 2000 年至 2020 年期间，34600 万人年的随访中，年龄在 15 至 39 岁之间的人群中，共有 349591 例新发糖尿病（包括两种类型）病例。随着时间的推移，匈牙利和日本的 1 型糖尿病发病率没有统计学意义的变化。澳大利亚、丹麦、芬兰、苏格兰、韩国和西班牙的 1 型糖尿病发病率显著增加，年变化率在 0.5%至 6.0%之间。丹麦、芬兰、日本和韩国四个司法管辖区的 2 型糖尿病发病率显著增加，年增长率为 2.0%至 8.5%。亚洲司法管辖区 2 型糖尿病发病率的增幅大于非亚洲司法管辖区。澳大利亚和匈牙利的 2 型糖尿病发病率没有统计学意义的变化。苏格兰和西班牙的 2 型糖尿病发病率显著下降，年变化率分别为-0.7%和-1.5%。
高收入国家或司法管辖区的青年发病 2 型糖尿病发病率轨迹存在差异，亚洲国家的发病率上升证据多于非亚洲国家。青年人群中 1 型和 2 型糖尿病发病率的演变趋势需要对糖尿病发病率进行持续监测，并加大对这一人群的研究力度。
美国疾病控制与预防中心、澳大利亚糖尿病协会研究计划和维多利亚州政府运营基础设施支持计划。
