Maasstad Hospital, Rotterdam, The Netherlands
Erasmus University Medical Center, Rotterdam, Zuid-Holland, The Netherlands.
BMJ Open. 2024 Nov 14;14(11):e088350. doi: 10.1136/bmjopen-2024-088350.
Musculoskeletal joint complaints (MSCs) are the most common extraintestinal manifestation of inflammatory bowel disease (IBD). We aimed to investigate the effect of MSC on the health-related quality of life (QoL) in patients with IBD.
A survey-based cross-sectional study among adult Dutch IBD patients.
Primary care, secondary care and patient association.
In total, 635 IBD patients were included. The mean age was 46.3 (SD 14.2) years, and 35% were male.
MSC was defined as suffering from any joint complaints. QoL was measured using the IBD questionnaire and a 36-item short form health survey questionnaire.
A univariate analysis was performed to estimate the impact of various factors, such as demographic characteristics, setting, type of IBD and fatigue, which was followed by a multiple regression analysis to adjust for the confounding factors.
Of the 635 IBD patients, 332 suffered from Crohn's disease (CD) and 303 from ulcerative colitis (UC). After adjusting for confounding factors, MSC was independently associated with reduced QoL among IBD patients (β=-10.6, 95% CI -15.2 to -6.1), both in CD (β=-8.3, 95% CI -14.6 to -2.1) and UC (β=-13.9, 95% CI -20.5 to -7.3). 11% of the IBD patients had a rheumatological diagnosis. QoL in these patients was significantly lower compared with IBD patients with non-rheumatological MSC.
IBD patients with MSC are associated with a lower QoL, explicitly in patients with a rheumatological diagnosis. Prospective research is necessary to evaluate the causality and suitable interventions to increase QoL in these multimorbid patients.
肌肉骨骼关节投诉（MSCs）是炎症性肠病（IBD）最常见的肠道外表现。我们旨在研究 MSCs 对 IBD 患者健康相关生活质量（QoL）的影响。
一项针对成年荷兰 IBD 患者的基于调查的横断面研究。
初级保健、二级保健和患者协会。
共纳入 635 名 IBD 患者。平均年龄为 46.3（SD 14.2）岁，35%为男性。
MSCs 定义为患有任何关节投诉。QoL 使用 IBD 问卷和 36 项简短健康调查问卷进行测量。
进行单变量分析以估计各种因素（如人口统计学特征、环境、IBD 类型和疲劳）的影响，然后进行多元回归分析以调整混杂因素。
在 635 名 IBD 患者中，332 名患有克罗恩病（CD），303 名患有溃疡性结肠炎（UC）。在调整混杂因素后，MSCs 与 IBD 患者的 QoL 降低独立相关（β=-10.6，95%CI-15.2 至-6.1），无论是在 CD（β=-8.3，95%CI-14.6 至-2.1）还是 UC（β=-13.9，95%CI-20.5 至-7.3）。11%的 IBD 患者有风湿病诊断。这些患者的 QoL 明显低于患有非风湿性 MSCs 的 IBD 患者。
患有 MSCs 的 IBD 患者的 QoL 较低，尤其是在有风湿病诊断的患者中。需要进行前瞻性研究来评估因果关系和适合的干预措施，以提高这些多病共存患者的 QoL。
