Mohit-Tabatabai M A, Dasmahapatra K S, Rush B F, Ohanian M
Am Surg. 1986 Mar;52(3):152-4.
Forty-three patients with the diagnosis of metastatic squamous cell carcinoma from unknown primary to the cervical lymph nodes were treated in EOVAMC between 1962-1982. Six of these patients were N1, 19 N2, and 18 N3. Five-year survival was 41 per cent for N1, 15 per cent for N2, and 6 per cent for N3 nodes. There was no significant difference in the treatment failure of those patients treated with unimodality versus multimodality. A subsequent primary was detected in the head and neck in 23 per cent of these patients (10/43), and eight of these patients had received previous radiotherapy. The most common site for these subsequent primaries was hypopharynx. Nine of the 43 patients developed distant metastasis with no correlation to stage of disease or treatment modality. These data show that the survival of these patients correlates with the stage of nodal disease, and that radiotherapy did not decrease the subsequent appearance of the primary lesions.
1962年至1982年间，43例诊断为不明原发灶的转移性鳞状细胞癌累及颈部淋巴结的患者在EOVAMC接受了治疗。其中6例为N1期，19例为N2期，18例为N3期。N1期患者的5年生存率为41%，N2期为15%，N3期为6%。单模式治疗与多模式治疗的患者在治疗失败方面无显著差异。这些患者中有23%（10/43）在头颈部发现了继发原发灶，其中8例患者曾接受过放疗。这些继发原发灶最常见的部位是下咽。43例患者中有9例发生远处转移，与疾病分期或治疗方式无关。这些数据表明，这些患者的生存率与淋巴结疾病分期相关，且放疗并未减少原发灶的后续出现。
