Atsukawa Natsuko, Tatekawa Hiroyuki, Ueda Daiju, Oura Tatsushi, Matsushita Shu, Horiuchi Daisuke, Takita Hirotaka, Mitsuyama Yasuhito, Baba Reia, Tsukamoto Taro, Shimono Taro, Miki Yukio
Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3, Asahi-Machi, Abeno-Ku, Osaka, 545-8585, Japan.
Department of Artificial Intelligence, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Neuroradiology. 2025 Mar;67(3):553-562. doi: 10.1007/s00234-024-03503-y. Epub 2024 Nov 15.
This study examined the correlation between tumor location and prognosis in patients with glioblastoma using magnetic resonance images of various isocitrate dehydrogenase (IDH) wild-type glioblastomas from The Cancer Imaging Archive (TCIA). The relationship between tumor location and prognosis was visualized using voxel-wise Cox regression analysis.
Participants with IDH wild-type glioblastoma were selected, and their survival and demographic data and tumor characteristics were collected from TCIA datasets. Post-contrast-enhanced T1-weighted imaging, T2-fluid attenuated inversion recovery imaging, and tumor segmentation data were also compiled. Following affine registration of each image and tumor segmentation region of interest to the MNI standard space, a voxel-wise Cox regression analysis was conducted. This analysis determined the association of the presence or absence of the tumor with the prognosis in each voxel after adjusting for the covariates.
The study included 769 participants of 464 men and 305 women (mean age, 63 years ± 12 [standard deviation]). The hazard ratio map indicated that tumors in the medial frontobasal region and around the third and fourth ventricles were associated with poorer prognoses, underscoring the challenges of complete resection and treatment accessibility in these areas regardless of the tumor volume. Conversely, tumors located in the right temporal and occipital lobes had favorable prognoses.
This study showed an association between tumor location and prognosis. These findings may assist clinicians in developing more precise and effective treatment plans for patients with glioblastoma to improve their management.
本研究利用来自癌症影像存档（TCIA）的各种异柠檬酸脱氢酶（IDH）野生型胶质母细胞瘤的磁共振图像，研究胶质母细胞瘤患者肿瘤位置与预后之间的相关性。使用体素级Cox回归分析可视化肿瘤位置与预后之间的关系。
选择IDH野生型胶质母细胞瘤患者，从TCIA数据集中收集他们的生存、人口统计学数据以及肿瘤特征。还收集了对比增强T1加权成像、T2液体衰减反转恢复成像和肿瘤分割数据。在将每个图像和肿瘤分割感兴趣区域仿射配准到MNI标准空间后，进行体素级Cox回归分析。该分析在调整协变量后确定每个体素中肿瘤的有无与预后的关联。
该研究纳入了769名参与者，其中464名男性和305名女性（平均年龄63岁±12[标准差]）。风险比图表明，额底内侧区域以及第三和第四脑室周围的肿瘤与较差的预后相关，这突出了这些区域无论肿瘤大小，在完全切除和治疗可及性方面的挑战。相反，位于右侧颞叶和枕叶的肿瘤预后良好。
本研究显示了肿瘤位置与预后之间的关联。这些发现可能有助于临床医生为胶质母细胞瘤患者制定更精确有效的治疗方案，以改善对他们的管理。
