Li Hong-Yu, Sun Chong-Ran, He Min, Yin Li-Chun, Du Hang-Gen, Zhang Jian-Min
Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Department of Neurosurgery, Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
World Neurosurg. 2018 Apr;112:e407-e414. doi: 10.1016/j.wneu.2018.01.055. Epub 2018 Jan 31.
Tumor location is a major prognostic factor in glioblastomas and may be associated with clinical properties. This study established and analyzed the correlation between tumor location and clinical properties of glioblastomas in frontal and temporal lobes.
This retrospective study determined the location of glioblastomas in the frontal lobe (FL) or temporal lobe (TL) based on preoperative magnetic resonance imaging. Clinical, radiologic, and molecular characteristics of FL and TL glioblastomas were compared to define their clinical properties, including sex, age, sides, relationship to ventricle, imaging subtypes, volume, isocitrate dehydrogenase mutation, promoter methylation of O-methylguanine-DNA methyltransferase, progression-free survival, and overall survival.
The study enrolled 406 patients (182 [44.83%] in FL group and 224 [55.17%] in TL group) with a mean age of 69.8 years. Compared with FL group, TL group had higher incidence of female patients (P = 0.024), tumor location distant to the ventricle (P = 0.006), isocitrate dehydrogenase mutations (P = 0.021), promoter methylation of O-methylguanine-DNA methyltransferase (P = 0.012), and prolonged progression-free survival and overall survival (P < 0.05). No significant differences were observed between groups with respect to age ≥60 years at study entry (P = 0.668), sides (P = 0.879), imaging subtypes (P = 0.362), or volume (P = 0.709).
This study demonstrated that different tumor locations are associated with diverse clinical properties of glioblastomas in FL and TL. This information will aid in increasing understanding of glioblastoma biology for application in baseline comparisons in future clinical trials.
肿瘤位置是胶质母细胞瘤的主要预后因素，可能与临床特征相关。本研究建立并分析了额叶和颞叶胶质母细胞瘤的肿瘤位置与临床特征之间的相关性。
这项回顾性研究根据术前磁共振成像确定胶质母细胞瘤位于额叶（FL）还是颞叶（TL）。比较FL和TL胶质母细胞瘤的临床、放射学和分子特征，以确定其临床特征，包括性别、年龄、部位、与脑室的关系、影像亚型、体积、异柠檬酸脱氢酶突变、O-甲基鸟嘌呤-DNA甲基转移酶启动子甲基化、无进展生存期和总生存期。
该研究纳入了406例患者（FL组182例[44.83%]，TL组224例[55.17%]），平均年龄69.8岁。与FL组相比，TL组女性患者发生率更高（P = 0.024），肿瘤位置远离脑室（P = 0.006），异柠檬酸脱氢酶突变（P = 0.021），O-甲基鸟嘌呤-DNA甲基转移酶启动子甲基化（P = 0.012），无进展生存期和总生存期延长（P < 0.05）。在研究入组时年龄≥60岁（P = 0.668）、部位（P = 0.879）、影像亚型（P = 0.362）或体积（P = 0.709）方面，两组之间未观察到显著差异。
本研究表明，不同的肿瘤位置与FL和TL胶质母细胞瘤的不同临床特征相关。这些信息将有助于加深对胶质母细胞瘤生物学的理解，以便在未来的临床试验中用于基线比较。
