Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Science, Kerman, Iran.
Department of Pediatric, School of Medicine, Afzalipour Hospital, Kerman University of Medical Science, Kerman, Iran.
BMC Infect Dis. 2024 Nov 14;24(1):1300. doi: 10.1186/s12879-024-10159-9.
The Global Point Prevalence Survey (PPS) of antimicrobial consumption and resistance has been widely undertaken to combat the global threat of antimicrobial resistance (AMR). This study was conducted in alignment with the Global-PPS in three tertiary care hospitals in Kerman, Iran, to evaluate antimicrobial consumption patterns.
The study was conducted from January 2020 to January 2021 in Afzalipour, Shafa, and Shahid Bahonar Hospitals. Data were collected using the standardized Global-PPS method at three different points throughout the year to minimize bias. Information on antimicrobial prescriptions, primary diagnosis, prophylaxis, therapy indications, and treatment type were documented. Antimicrobial prevalence was calculated using the total number of admitted patients as the denominator and those on antimicrobial regimens as the numerator.
The point prevalence of antimicrobial consumption in adult wards was 65.6% in Afzalipour Hospital, 42.3% in Shafa Hospital, and 78.7% in Bahonar Hospital. Non-penicillin beta-lactams, macrolides, lincosamides, and streptogramins were the most frequently prescribed antibiotic classes. Approximately 80% of prescriptions had explicit reasons documented, and targeted antibiotic therapy rates varied between 7.7% and 44.8% across hospitals.
Antimicrobial consumption in Kerman's tertiary care hospitals exceeded national and global levels, indicating an urgent need for interventions to promote rational antibiotic use. Infection control committees must implement rigorous monitoring measures to reduce antimicrobial resistance. Ongoing surveillance and targeted interventions are essential to curb the rising rates of antimicrobial resistance in the region.
全球抗菌药物使用率和耐药率的点 prevalence 调查（PPS）广泛开展，以应对全球抗菌药物耐药性（AMR）威胁。本研究与全球 PPS 一致，在伊朗克尔曼的三家三级保健医院进行，以评估抗菌药物使用模式。
该研究于 2020 年 1 月至 2021 年 1 月在阿夫扎利普尔、沙法和巴赫纳尔医院进行。使用标准化的全球 PPS 方法在全年三个不同时间点收集数据，以尽量减少偏倚。记录了抗菌药物处方、主要诊断、预防、治疗指征和治疗类型的信息。抗菌药物流行率的计算方法是将住院患者总数作为分母，将接受抗菌药物治疗的患者数作为分子。
成人病房抗菌药物使用率的时点流行率在阿夫扎利普尔医院为 65.6%，在沙法医院为 42.3%，在巴赫纳尔医院为 78.7%。非青霉素类β-内酰胺类、大环内酯类、林可酰胺类和链阳性菌素类是最常开的抗生素类别。大约 80%的处方有明确的记录原因，各医院的靶向抗生素治疗率在 7.7%至 44.8%之间不等。
克尔曼三级保健医院的抗菌药物使用率高于国家和全球水平，表明迫切需要采取干预措施促进合理使用抗生素。感染控制委员会必须实施严格的监测措施，以减少抗菌药物耐药性。需要进行持续监测和针对性干预，以遏制该地区抗菌药物耐药率的上升。
