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载有倍他米松二丙酸酯的锌掺杂介孔硅纳米粒子的微针贴片用于治疗银屑病。

Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment.

机构信息

Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.

Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, China.

出版信息

J Nanobiotechnology. 2024 Nov 14;22(1):706. doi: 10.1186/s12951-024-02986-4.

DOI:10.1186/s12951-024-02986-4
PMID:39543615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11562306/
Abstract

Treating psoriasis presents a major clinical challenge because of the limitations associated with traditional topical glucocorticoid therapy. This study introduced a drug delivery system utilizing zinc-doped mesoporous silica nanoparticle (Zn-MSN) and microneedle (MN), designed to enhance drug utilization for prolonged anti-inflammatory and anti-itch effects. The MN system facilitated the transdermal delivery of betamethasone dipropionate (BD), allowing its slow release. The BD@Zn-MSN-MN system promoted the polarization of macrophages towards the anti-inflammatory M2 phenotype, achieving superior anti-inflammatory effects compared to the clinically used BD cream. Additionally, this study demonstrated that BD@Zn-MSN-MN could further alleviate itching in psoriasis-afflicted mice by decreasing the excitability of the transient receptor potential vanilloid V1 (TRPV1) ion channel positive neurons and reducing the release of calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG). These findings offer new insights and effective therapeutic options for the future design of transdermal drug delivery for psoriasis.

摘要

治疗银屑病存在重大的临床挑战，因为传统的局部糖皮质激素治疗存在局限性。本研究引入了一种利用锌掺杂介孔硅纳米粒子（Zn-MSN）和微针（MN）的药物传递系统，旨在通过增强药物利用来实现长效抗炎和止痒效果。MN 系统促进了倍他米松双丙酸酯（BD）的经皮传递，实现了其缓慢释放。BD@Zn-MSN-MN 系统促进了巨噬细胞向抗炎 M2 表型的极化，与临床上使用的 BD 乳膏相比，具有更优异的抗炎效果。此外，本研究表明，BD@Zn-MSN-MN 还可以通过降低瞬时受体电位香草素 V1（TRPV1）离子通道阳性神经元的兴奋性和减少背根神经节（DRG）中降钙素基因相关肽（CGRP）的释放，进一步减轻银屑病小鼠的瘙痒。这些发现为未来设计用于银屑病的经皮药物传递系统提供了新的见解和有效的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/f54c3295e339/12951_2024_2986_Fig9_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/f54c3295e339/12951_2024_2986_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/0e297bf60961/12951_2024_2986_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/a95af243ba6d/12951_2024_2986_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/ff04c6c328dd/12951_2024_2986_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/bb486e6b072a/12951_2024_2986_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/cb64c49b20cf/12951_2024_2986_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/1134d77af486/12951_2024_2986_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/1e1e9fecda60/12951_2024_2986_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9f/11562306/f54c3295e339/12951_2024_2986_Fig9_HTML.jpg

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