人类红细胞己糖激酶在免疫学上相关。

Human erythrocyte hexokinases are immunologically related.

作者信息

Magnani M, Chiarantini L, Serafini G, Stocchi V, Dachà M, Fornaini G

出版信息

Arch Biochem Biophys. 1986 Mar;245(2):540-2. doi: 10.1016/0003-9861(86)90248-1.

Abstract

Human erythrocytes contain three major hexokinase isoenzymes eluted by DE-52 chromatography between hexokinase type I and type II. Cross-reactivities of these isoenzymes were studied by means of a monospecific rabbit antibody against purified human placenta hexokinase type I. It was shown that the three hexokinase isoenzymes were immunologically related, supporting the concept of a postsynthetic mechanism(s) as their origin.

摘要

人红细胞含有三种主要的己糖激酶同工酶，通过DE-52柱层析在己糖激酶I型和II型之间洗脱出来。用针对纯化的人胎盘己糖激酶I型的单特异性兔抗体研究了这些同工酶的交叉反应性。结果表明，这三种己糖激酶同工酶在免疫学上相关，支持了它们起源于合成后机制的概念。