Hamada H, Asakura T, Maeda Y, Yokoyama S, Niiro M
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 1):464-71.
The direct antitumoral effect of interferon-alpha on human glioma was suggested in a study involving tissue culture, and scanning and transmission electron microscopy. Consequently, intratumoral local administration of interferon-alpha for four cases of human glioma was performed, and each survival period from the initiation of its application was seven, eight, three and two months. Slight direct antitumoral effect of interferon was observed in the findings of both CT scan and autopsy in our series, but the survival time was not as great as we had expected. One of the reasons for this was thought to be insufficient permeability of interferon-alpha into the residual infiltrating tumor tissue. Therefore, the use of systemic administration of interferon or another adjuvant therapy with local administration of interferon would be expected to produce better results.
一项涉及组织培养、扫描和透射电子显微镜的研究表明，α干扰素对人类胶质瘤有直接抗肿瘤作用。因此，对4例人类胶质瘤患者进行了瘤内局部注射α干扰素治疗，自开始应用后的生存期分别为7个月、8个月、3个月和2个月。在我们的系列研究中，CT扫描和尸检结果均观察到干扰素具有轻微的直接抗肿瘤作用，但生存时间不如预期。其中一个原因被认为是α干扰素向残留浸润性肿瘤组织的渗透性不足。因此，使用干扰素全身给药或与干扰素局部给药联合其他辅助治疗有望产生更好的效果。
