Jacobs Howard T, Rustin Pierre, Bénit Paule, Davidi Dan, Terzioglu Mügen
Faculty of Medicine and Health Technology, Tampere University, Finland.
Department of Environment and Genetics, La Trobe University, Melbourne, Australia.
FEBS J. 2024 Dec;291(24):5327-5341. doi: 10.1111/febs.17316. Epub 2024 Nov 14.
Recent experimental studies indicate that mitochondria in mammalian cells are maintained at temperatures of at least 50 °C. While acknowledging the limitations of current experimental methods and their interpretation, we here consider the ramifications of this finding for cellular functions and for evolution. We consider whether mitochondria as heat-producing organelles had a role in the origin of eukaryotes and in the emergence of homeotherms. The homeostatic responses of mitochondrial temperature to externally applied heat imply the existence of a molecular heat-sensing system in mitochondria. While current findings indicate high temperatures for the innermost compartments of mitochondria, those of the mitochondrial surface and of the immediately surrounding cytosol remain to be determined. We ask whether some aspects of mitochondrial dynamics and motility could reflect changes in the supply and demand for mitochondrial heat, and whether mitochondrial heat production could be a factor in diseases and immunity.
最近的实验研究表明，哺乳动物细胞中的线粒体维持在至少50°C的温度。在承认当前实验方法及其解释存在局限性的同时，我们在此考虑这一发现对细胞功能和进化的影响。我们思考作为产热细胞器的线粒体是否在真核生物起源和恒温动物出现过程中发挥了作用。线粒体温度对外加热量的稳态反应意味着线粒体中存在分子热传感系统。虽然目前的研究结果表明线粒体最内部区域温度较高，但线粒体表面及其紧邻的胞质溶胶的温度仍有待确定。我们探讨线粒体动力学和运动性的某些方面是否能反映线粒体热量供需的变化，以及线粒体产热是否可能是疾病和免疫中的一个因素。
