顺铂对儿童难治性恶性肿瘤的作用
[Effects of cis-DDP in children with refractory malignant tumors].
作者信息
Nakadate H, Kobayashi R, Nishi M, Hatae Y, Takeda T, Uchino J, Hirama T, Kobayashi H
出版信息
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 1):598-603.
Eighteen children with refractory malignant tumors were treated with cis-DDP. They included 10 neuroblastomas, 2 rhabdomyosarcomas, and one each of hepatoblastoma, yolk sac tumor, osteosarcoma and pinealoma. Of 7 cases treated only with cis-DDP, 2 were NC, 6 PD and none were CR or PR. Of 11 cases treated with cis-DDP combined with other agents, 7 were PR, 2 NC, 2 PD and none were CR. The major side effect of cis-DDP was renal toxicity, but this was not serious and only transient. Three cases were treated with the continuous intra-arterial infusion method. These included 2 neuroblastomas and one yolk sac tumor. This treatment was therefore highly effective for children with malignant tumors, and few side effects were observed.
18例难治性恶性肿瘤患儿接受了顺铂治疗。其中包括10例神经母细胞瘤、2例横纹肌肉瘤，以及各1例肝母细胞瘤、卵黄囊瘤、骨肉瘤和松果体瘤。仅接受顺铂治疗的7例中，2例病情稳定（NC），6例病情进展（PD），无完全缓解（CR）或部分缓解（PR）者。接受顺铂联合其他药物治疗的11例中，7例部分缓解（PR），2例病情稳定（NC），2例病情进展（PD），无完全缓解（CR）者。顺铂的主要副作用是肾毒性，但并不严重，且只是短暂性的。3例采用持续动脉内灌注法治疗。其中包括2例神经母细胞瘤和1例卵黄囊瘤。因此，这种治疗方法对患有恶性肿瘤的儿童非常有效，且观察到的副作用很少。
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