Sawa R, Miyao M, Muchi H, Kamoshita S, Nihei K
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 1):616-9.
The effect of cisplatin on the auditory nervous system was examined in five children using brainstem auditory evoked potentials (BAEPs). The cases comprized of two neuroblastoma, one yolk sac tumor one neurofibrosarcoma and one Hodgkin's disease. All patients except for one infant aged eight months showed a normal audiogram in the pre-treatment examination. Cisplatin was administered at a dose of 75-105 mg/m2 (body surface area). BAEP tests were performed after cisplatin treatment from two weeks to 20 months. The patients were tested at rest in bed using stimulation with a 3 KHz, 80-dBHL click at 150-msec intervals 2,000 times. Four cases showed an abnormal BAEP pattern in the post-treatment examination. Two of them showed not only delayed conduction velocity of the first wave but also auditory disturbance, but these findings were improved after discontinuation of drug administration. We concluded that cisplatin frequently affects the auditory nervous system, and that this disturbance might be transient in the early stage.
使用脑干听觉诱发电位（BAEP）对5名儿童的顺铂对听觉神经系统的影响进行了检查。病例包括2例神经母细胞瘤、1例卵黄囊瘤、1例神经纤维肉瘤和1例霍奇金病。除1名8个月大的婴儿外，所有患者在治疗前检查时听力图均正常。顺铂的给药剂量为75 - 105 mg/m²（体表面积）。在顺铂治疗后2周~20个月进行BAEP测试。患者在床上休息时接受测试，使用3 kHz、80 dBHL的短声以150毫秒的间隔进行刺激，共刺激2000次。4例患者在治疗后检查中显示BAEP模式异常。其中2例不仅第一波传导速度延迟，还出现听觉障碍，但在停药后这些表现有所改善。我们得出结论，顺铂经常影响听觉神经系统，并且这种干扰在早期可能是短暂的。
