Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
J Cosmet Dermatol. 2023 Jul;22(7):2099-2104. doi: 10.1111/jocd.15676. Epub 2023 Feb 9.
To compare complete blood count (CBC) parameters and inflammatory factors in the patients with different grade of acne vulgaris and healthy controls.
A total of 20 patients were enrolled in this study. Patients were divided into mild group and moderate-to-severe group based on the acne severity, and compared to controls. Inflammatory factors (TNF-α, IL-6, IL-8, and IL1-α) detected by ELISA and complete blood count parameters (MPV, NLR, dNLR, PLR, LMR, and SII) obtained by routine blood tests were compared among the three group.
All CBC parameters were not significantly elevated in patients with acne compared to healthy controls. However, the present studies have found that the inflammatory factors in acne patients were significantly elevated relative to healthy controls, and increase with the acne grade.
Inflammatory factors are convenient parameters to show inflammatory response to acne vulgaris, and may be a new clinical method for judging the acne grades of objectively. Considering the use of antibiotic, we believe that this metric worth further study.
比较不同严重程度寻常痤疮患者与健康对照者的血常规参数和炎症因子。
共纳入 20 例患者，根据痤疮严重程度分为轻度组和中重度组，并与对照组进行比较。采用酶联免疫吸附试验（ELISA）检测炎症因子（TNF-α、IL-6、IL-8 和 IL1-α），常规血液检查获得血常规参数（MPV、NLR、dNLR、PLR、LMR 和 SII），并对三组进行比较。
与健康对照组相比，寻常痤疮患者的所有血常规参数均无明显升高。然而，本研究发现，寻常痤疮患者的炎症因子明显高于健康对照组，并随痤疮分级而增加。
炎症因子是反映寻常痤疮炎症反应的方便参数，可能是客观判断痤疮分级的新临床方法。考虑到抗生素的使用，我们认为该指标值得进一步研究。
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