Peoples Brandon M, Harrison Kenneth D, Renfrow Grant, Bethea Douglas, Santamaria Guzman Keven G, Wilson Alan E, Samaan Michael A, Roper Jaimie A
School of Kinesiology, Auburn University, Auburn, USA.
Department of Anesthesiology and Perioperative Medicine, Edward Via College of Osteopathic Medicine, Auburn University, Auburn, USA.
Cureus. 2024 Oct 14;16(10):e71458. doi: 10.7759/cureus.71458. eCollection 2024 Oct.
Osteoarthritis (OA) is a highly prevalent joint disorder that is emerging as a global threat to health. OA is associated with low-grade chronic systemic inflammation that can affect overall health, leading to a sedentary lifestyle and potentially increased risk of neurological disorders (ND) such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). A meta-analysis was conducted following the Preferred Reporting Items for 2020 Systematic Reviews and Meta-Analyses (PRISMA) guidelines. MEDLINE, Web of Science, and Embase databases were searched to identify records. The inclusion criteria for this analysis were original research articles reporting on OA and neurological disorder diagnoses (AD, PD, or MS) with non-OA comparator groups. Logarithmic odds ratios (LORs) were calculated and input into a random-effects meta-analysis using the restricted maximum-likelihood estimator. Subgroup analyses examined the associations between OA, AD, PD, and MS. A subsequent meta-regression analysis was performed to explore potential sources of heterogeneity, focusing on comorbidities and demographic factors. Publication bias was evaluated using funnel plots, Egger's test, and trim-and-fill analysis. Nine studies were included in this meta-analysis (six case-control designs, two cross-sectional designs, and one population-based cohort design) of 1,837,716 cases. The pooled odds ratio (OR) indicated a significant association between OA and ND diagnosis (OR = 1.246; confidence interval (CI): 1.01-1.53). Subsequent subgroup analyses were not statistically significant but indicated an association with PD (OR = 1.31, CI: 0.80-2.12), MS (OR = 1.12, CI: 0.80-2.81), and AD (OR = 1.50, CI: 0.80-2.81). This meta-analysis revealed that individuals with OA have approximately 25% higher odds of an accompanying ND diagnosis compared to those without OA. Importantly, these findings represent statistical associations only and do not imply causation or directionality but provide insight into factors, including shared risk factors, overlapping symptoms, or other underlying mechanisms that may influence the observed relationships.
骨关节炎（OA）是一种高度常见的关节疾病，正成为对健康的全球性威胁。OA与低度慢性全身性炎症相关，这种炎症会影响整体健康，导致久坐不动的生活方式，并可能增加患神经疾病（ND）的风险，如阿尔茨海默病（AD）、帕金森病（PD）和多发性硬化症（MS）。按照2020年系统评价和Meta分析的首选报告项目（PRISMA）指南进行了一项Meta分析。检索了MEDLINE、科学网和Embase数据库以识别记录。该分析的纳入标准是报告OA和神经疾病诊断（AD、PD或MS）并设有非OA对照人群的原始研究文章。计算对数比值比（LOR），并使用受限最大似然估计器将其输入随机效应Meta分析。亚组分析研究了OA、AD、PD和MS之间的关联。随后进行了Meta回归分析，以探索异质性的潜在来源，重点关注合并症和人口统计学因素。使用漏斗图、Egger检验和修剪填充分析评估发表偏倚。该Meta分析纳入了9项研究（6项病例对照设计、2项横断面设计和1项基于人群的队列设计），共1837716例病例。合并比值比（OR）表明OA与ND诊断之间存在显著关联（OR = 1.246；置信区间（CI）：1.01 - 1.53）。随后的亚组分析无统计学意义，但显示与PD（OR = 1.31，CI：0.80 - 2.12）、MS（OR = 1.12，CI：0.80 - 2.81）和AD（OR = 1.50，CI：0.80 - 2.81）有关联。该Meta分析表明，与无OA的个体相比，患有OA的个体伴随ND诊断的几率高出约25%。重要的是，这些发现仅代表统计关联，并不意味着因果关系或方向性，但为包括共同风险因素、重叠症状或其他可能影响观察到的关系的潜在机制在内的因素提供了见解。
