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通过16s rRNA基因测序诊断出的一名免疫功能正常年轻男性的无数培养阴性颅内脓肿

Innumerable Culture-Negative Intracranial Abscesses in an Immunocompetent Young Male Diagnosed by 16s rRNA Gene Sequencing.

作者信息

Miller Ronald A, Kim Yeonsoo, Pryshliak Vasyl, Beutler Timothy M

机构信息

Neurology, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

Neurosurgery, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

出版信息

Cureus. 2024 Oct 14;16(10):e71475. doi: 10.7759/cureus.71475. eCollection 2024 Oct.

DOI:10.7759/cureus.71475
PMID:39544588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11560407/
Abstract

Here, we present a case of a healthy young man with an initial presentation concerning for infectious encephalitis later found on neuroimaging to have extensive intracranial lesions. Pathological analysis of these lesions was consistent with a bacterial intraparenchymal abscess; however, cultures were negative for a causative organism. Results of gene sequencing from an abscess sample were consistent with infection. , a β-hemolytic gram-positive species of the group (SAG), is known to possess several virulence factors that promote abscess formation.

摘要

在此，我们报告一例健康年轻男性病例，其最初表现疑似感染性脑炎，后来神经影像学检查发现有广泛的颅内病变。这些病变的病理分析与细菌性脑实质脓肿一致；然而，培养未发现致病微生物。脓肿样本的基因测序结果与感染相符。已知A组链球菌（SAG）中的一种β溶血性革兰氏阳性菌具有多种促进脓肿形成的毒力因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/c2c959ae5256/cureus-0016-00000071475-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/0519a92cd640/cureus-0016-00000071475-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/4561aedf8254/cureus-0016-00000071475-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/9cc8b48a4934/cureus-0016-00000071475-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/0750a64ae643/cureus-0016-00000071475-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/c2c959ae5256/cureus-0016-00000071475-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/0519a92cd640/cureus-0016-00000071475-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/4561aedf8254/cureus-0016-00000071475-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/9cc8b48a4934/cureus-0016-00000071475-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/0750a64ae643/cureus-0016-00000071475-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a17/11560407/c2c959ae5256/cureus-0016-00000071475-i05.jpg

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本文引用的文献

1
The Brief Case: Streptococcus intermedius Brain Abscesses in an Otherwise Healthy Young Man Diagnosed by 16S rRNA Gene Sequencing.病例简报：通过16S rRNA基因测序诊断一名原本健康的年轻男性的中间型链球菌脑脓肿
J Clin Microbiol. 2022 Jan 19;60(1):e0197020. doi: 10.1128/JCM.01970-20.
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Clinical Characteristics of Infections Caused by Streptococcus Anginosus Group.咽峡炎链球菌群感染的临床特征。
Sci Rep. 2020 Jun 3;10(1):9032. doi: 10.1038/s41598-020-65977-z.
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From Normal Flora to Brain Abscesses: A Review of .从正常菌群到脑脓肿：综述…… （原文不完整）
Front Microbiol. 2020 May 7;11:826. doi: 10.3389/fmicb.2020.00826. eCollection 2020.
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An update on bacterial brain abscess in immunocompetent patients.免疫功能正常患者细菌性脑脓肿的最新研究进展。
Clin Microbiol Infect. 2017 Sep;23(9):614-620. doi: 10.1016/j.cmi.2017.05.004. Epub 2017 May 10.
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Bacterial brain abscess.细菌性脑脓肿
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Brain abscess.脑脓肿
N Engl J Med. 2014 Jul 31;371(5):447-56. doi: 10.1056/NEJMra1301635.
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Invasive Streptococcus anginosus group infection-does the species predict the outcome?侵袭性咽峡炎链球菌群感染-菌种是否能预测结局？
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The role of Streptococcus intermedius in brain abscess.中间链球菌在脑脓肿中的作用。
Eur J Clin Microbiol Infect Dis. 2013 Apr;32(4):477-83. doi: 10.1007/s10096-012-1782-8. Epub 2012 Nov 28.
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Pyrosequencing reveals the complex polymicrobial nature of invasive pyogenic infections: microbial constituents of empyema, liver abscess, and intracerebral abscess.焦磷酸测序揭示侵袭性化脓性感染的复杂多微生物性质：脓胸、肝脓肿和脑脓肿的微生物组成。
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Culture-negative brain abscess with Streptococcus intermedius infection with diagnosis established by direct nucleotide sequence analysis of the 16s ribosomal RNA gene.通过对16S核糖体RNA基因进行直接核苷酸序列分析确诊的中间型链球菌感染所致培养阴性脑脓肿
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