Golestan Rheumatology Research Center, Golestan University of Medical Science, Gorgan, Iran.
Department of Nutrition, School of Agricultural Sciences and Veterinary Medicine, University of Padua, Padua, Italy.
Eur J Nutr. 2024 Nov 15;64(1):8. doi: 10.1007/s00394-024-03515-7.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multisystem involvement. This study was designed to examine the effects of curcumin, a polyphenolic compound isolated from turmeric rhizomes, on inflammatory markers in SLE patients.
Seventy 18-60 years old SLE patients were recruited in this randomized triple-blinded placebo-controlled trial, and 62 completed the study. Curcumin group received 1000 mg curcumin daily and the placebo group received placebo capsules for 10 weeks. Dietary intakes and serum levels of complement C3 and C4, complement hemolytic 50%, rheumatoid factor, anti-double stranded DNA (anti-ds DNA), erythrocyte sedimentation rate, high-sensitivity C-reactive protein, interlukine-6 (IL-6) and tumor necrosis factor-α were assessed before and after intervention period.
Curcumin supplementation caused a significant reduction in anti-ds DNA and IL-6 levels at the end of the trial in comparison with baseline (52.57 ± 40.21 vs. 43.27 ± 28.34, p = 0.014 and 127.11 ± 76.63 vs. 101.49 ± 59.08, p = 0.002, respectively). Analysis of covariance which was adjusted for confounding variables also revealed that anti-ds DNA and IL-6 levels decreased significantly in curcumin group compared to placebo group by the end of the intervention period (change:-9.30 ± 19.59 vs. -2.55 ± 17.55, p = 0.018 and - 25.62 ± 42.33 vs. -7.34 ± 34.32, p = 0.043, respectively). No significant changes were observed in levels of other variables during the study (p > 0.05).
Curcumin as an effective and safe adjuvant therapy, ameliorated the autoimmune activity and inflammation in SLE patients via reducing anti-ds DNA and IL-6 levels.
irct.behdasht.gov.ir, identifier: IRCT20210425051077N1.
系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，可累及多个系统。本研究旨在探讨姜黄素（一种从姜黄根茎中分离出的多酚化合物）对 SLE 患者炎症标志物的影响。
本随机、三盲、安慰剂对照试验共招募了 70 名 18-60 岁的 SLE 患者，其中 62 名完成了研究。姜黄素组每天接受 1000mg 姜黄素治疗，安慰剂组接受安慰剂胶囊治疗 10 周。在干预前后评估了膳食摄入量和血清补体 C3 和 C4、补体溶血 50%、类风湿因子、抗双链 DNA（抗 dsDNA）、红细胞沉降率、高敏 C 反应蛋白、白细胞介素-6（IL-6）和肿瘤坏死因子-α的水平。
与基线相比，姜黄素补充剂在试验结束时显著降低了抗 dsDNA 和 IL-6 水平（52.57±40.21 对 43.27±28.34，p=0.014 和 127.11±76.63 对 101.49±59.08，p=0.002）。调整混杂因素的协方差分析也显示，与安慰剂组相比，姜黄素组在干预期末抗 dsDNA 和 IL-6 水平显著降低（变化：-9.30±19.59 对-2.55±17.55，p=0.018 和-25.62±42.33 对-7.34±34.32，p=0.043）。研究期间，其他变量的水平无明显变化（p>0.05）。
姜黄素作为一种有效和安全的辅助治疗方法，通过降低抗 dsDNA 和 IL-6 水平，改善了 SLE 患者的自身免疫活性和炎症。
irct.behdasht.gov.ir，标识符：IRCT20210425051077N1。
