Rojo-Alba Susana, González-Alba José María, Martínez Zulema Pérez, Varela Cristina Ochoa, Álvarez Maria Agustina Alonso, Fernández Pablo Rubianes, Pérez Mercedes Rodríguez, García Estibaliz Garrido, Boga José Antonio, García Santiago Melón, Álvarez-Argüelles Marta Elena
Microbiology Department, Instituto de Investigación Sanitaria del Principado de Asturias, Hospital Universitario Central de Asturias, Avn Roma s/n, Oviedo, 33011, Spain.
Pediatric Department, Hospital Universitario Central de Asturias, Avn Roma s/n, Oviedo, 33011, Spain.
Eur J Clin Microbiol Infect Dis. 2025 Jan;44(1):197-207. doi: 10.1007/s10096-024-04970-0. Epub 2024 Nov 15.
Enteroviruses (EVs) are a large group of genotypes that cause a variety of pathologies, some of them very serious. This study analyzed the last 10 years (2014-2023) of EVs diagnosis and classification. In 166,674 samples collected, EVs were found in 9,535 (5.7%) by rt-RT-PCR, and 332 (3.5%) were classified by Sanger methods. Symptoms were analyzed in 7623 cases. EVs were found in 5718/63,829 (8.9%) before, 1384/42,373 (3.3%) during and 2433/60,472 (4%) after the Covid pandemic (p < 0.0001), and in 7249/69,700 (10.4%) children under 6 years and in 2286/96,974 (2.35%) in oldest (p < 0.0001). The positive rate of EVs was high but decreased during the Covid period. In the youngest children EVs-A (associated with exantematohous disorders as well as respiratory manifestations and febrile syndromes) was most common, while EVs-B (frequent in neurological symptoms) was most common in children aged 6-15 years and EVs-D (associated to respiratory manifestations) in adults.
肠道病毒（EVs）是一大类基因型病毒，可导致多种病理状况，其中一些非常严重。本研究分析了过去10年（2014 - 2023年）肠道病毒的诊断和分类情况。在收集的166,674份样本中，通过逆转录-实时聚合酶链反应（rt-RT-PCR）检测到9,535份（5.7%）存在肠道病毒，通过桑格法对332份（3.5%）进行了分类。对7623例病例的症状进行了分析。在新冠疫情之前，63,829例中有5718例（8.9%）检测到肠道病毒；疫情期间，42,373例中有1384例（3.3%）；疫情之后，60,472例中有2433例（4%）（p < 0.0001）。6岁以下儿童中，69,700例中有7249例（10.4%）检测到肠道病毒；年龄较大者中，96,974例中有2286例（2.35%）（p < 0.0001）。肠道病毒的阳性率较高，但在新冠疫情期间有所下降。在年龄最小的儿童中，肠道病毒A（与皮疹性疾病以及呼吸道表现和发热综合征相关）最为常见，而肠道病毒B（在神经症状中常见）在6 - 15岁儿童中最为常见，肠道病毒D（与呼吸道表现相关）在成年人中最为常见。
