Fox Aine, Hayes Breda, Doyle Emma
Department of Neonatology, Rotunda Hospital, Dublin, Ireland; Royal College of Surgeons (RCSI), Dublin, Ireland.
Department of Histopathology, Rotunda Hospital, Dublin, Ireland.
Semin Fetal Neonatal Med. 2024 Nov;29(2-3):101549. doi: 10.1016/j.siny.2024.101549. Epub 2024 Nov 7.
Perinatal medicine has made significant advancements in recent decades. This has improved care and outcomes for infants. As we strive to improve neurodevelopmental outcomes, we must understand the influence the maternal/placental/fetal (MPF) triad has on fetal development and postnatal health and disease. Our understanding of the MPF triad remains incomplete, however research is continuing to develop our understanding. Through further research and incorporating what is currently known into how we deliver perinatal care, we have the opportunity to improve outcomes for infants. This review focuses on what is currently known about the structure and function of the placenta and the influence of the MPF triad. Current modalities for assessment of the MPF triad and future avenues for research will also be discussed. Understanding the relationship between the MPF triad, neurodevelopment and long-term health and disease has the potential to open new avenues for disease prevention and treatment through the lifespan.
近几十年来，围产期医学取得了重大进展。这改善了对婴儿的护理及预后。在我们努力改善神经发育预后的过程中，我们必须了解母体/胎盘/胎儿（MPF）三联体对胎儿发育以及出生后健康和疾病的影响。然而，我们对MPF三联体的理解仍不完整，不过研究仍在不断加深我们的认识。通过进一步研究并将目前已知的知识纳入我们提供围产期护理的方式中，我们有机会改善婴儿的预后。本综述聚焦于目前已知的胎盘结构和功能以及MPF三联体的影响。还将讨论评估MPF三联体的当前方法以及未来的研究途径。了解MPF三联体、神经发育与长期健康和疾病之间的关系，有可能为贯穿一生的疾病预防和治疗开辟新途径。
