• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

非小细胞肺癌患者的唾液脂质与血浆脂质相比表现出紊乱。

Salivary Lipids of Patients with Non-Small Cell Lung Cancer Show Perturbation with Respect to Plasma.

机构信息

Department of Chemistry, Yonsei University, Seodaemun-gu, Seoul 03722, Republic of Korea.

Institute of Health Sciences, Department of Basic Oncology, Ege University, Izmir 35040, Turkey.

出版信息

Int J Mol Sci. 2023 Sep 19;24(18):14264. doi: 10.3390/ijms241814264.

DOI:10.3390/ijms241814264
PMID:37762567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10531690/
Abstract

A comprehensive lipid profile was analyzed in patients with non-small cell lung cancer (NSCLC) using nanoflow ultrahigh-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. This study investigated 297 and 202 lipids in saliva and plasma samples, respectively, comparing NSCLC patients to healthy controls. Lipids with significant changes (>2-fold, < 0.05) were further analyzed in each sample type. Both saliva and plasma exhibited similar lipid alteration patterns in NSCLC, but saliva showed more pronounced changes. Total triglycerides (TGs) increased (>2-3-fold) in plasma and saliva samples. Three specific TGs (50:2, 52:5, and 54:6) were significantly increased in NSCLC for both sample types. A common ceramide species (d18:1/24:0) and phosphatidylinositol 38:4 decreased in both plasma and saliva by approximately two-fold. Phosphatidylserine 36:1 was selectively detected in saliva and showed a subsequent decrease, making it a potential biomarker for predicting lung cancer. We identified 27 salivary and 10 plasma lipids as candidate markers for NSCLC through statistical evaluations. Moreover, this study highlights the potential of saliva in understanding changes in lipid metabolism associated with NSCLC.

摘要

采用纳流超高效液相色谱-电喷雾串联质谱法对非小细胞肺癌（NSCLC）患者进行了全面的脂质谱分析。本研究分别对 297 名和 202 名唾液和血浆样本中的 NSCLC 患者和健康对照者进行了比较。对差异有统计学意义的脂质（>2 倍，<0.05）在每种样本类型中进行了进一步分析。唾液和血浆在 NSCLC 中均表现出相似的脂质改变模式，但唾液显示出更明显的变化。血浆和唾液样本中的总甘油三酯（TGs）均增加（>2-3 倍）。两种样本类型中，三种特定的 TG（50:2、52:5 和 54:6）均显著增加。一种常见的神经酰胺种类（d18:1/24:0）和磷脂酰肌醇 38:4 在血浆和唾液中均减少约两倍。唾液中选择性检测到的磷脂酰丝氨酸 36:1 随后减少，使其成为预测肺癌的潜在生物标志物。通过统计学评估，我们在唾液中鉴定出 27 种和血浆中鉴定出 10 种候选 NSCLC 脂质标志物。此外，本研究强调了唾液在理解与 NSCLC 相关的脂质代谢变化方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/b98f0484a5e7/ijms-24-14264-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/380caff67abf/ijms-24-14264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/59f3d952ea2d/ijms-24-14264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/aa4ba95dd671/ijms-24-14264-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/857d937050ab/ijms-24-14264-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/388b816c12c6/ijms-24-14264-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/b98f0484a5e7/ijms-24-14264-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/380caff67abf/ijms-24-14264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/59f3d952ea2d/ijms-24-14264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/aa4ba95dd671/ijms-24-14264-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/857d937050ab/ijms-24-14264-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/388b816c12c6/ijms-24-14264-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47f9/10531690/b98f0484a5e7/ijms-24-14264-g006.jpg

相似文献

1
Salivary Lipids of Patients with Non-Small Cell Lung Cancer Show Perturbation with Respect to Plasma.非小细胞肺癌患者的唾液脂质与血浆脂质相比表现出紊乱。
Int J Mol Sci. 2023 Sep 19;24(18):14264. doi: 10.3390/ijms241814264.
2
Plasma lipid profile comparison of five different cancers by nanoflow ultrahigh performance liquid chromatography-tandem mass spectrometry.采用纳流超高效液相色谱-串联质谱法比较五种不同癌症的血浆脂质谱。
Anal Chim Acta. 2019 Jul 31;1063:117-126. doi: 10.1016/j.aca.2019.02.021. Epub 2019 Feb 19.
3
Optimisation of saliva volumes for lipidomic analysis by nanoflow ultrahigh performance liquid chromatography-tandem mass spectrometry.通过纳流超高效液相色谱-串联质谱法优化脂质组学分析中的唾液量。
Anal Chim Acta. 2022 Feb 8;1193:339318. doi: 10.1016/j.aca.2021.339318. Epub 2021 Nov 23.
4
Assessment of plasma amino acids, purines, tricarboxylic acid cycle metabolites, and lipids levels in NSCLC patients based on LC-MS/MS quantification.基于 LC-MS/MS 定量检测 NSCLC 患者的血浆氨基酸、嘌呤、三羧酸循环代谢物和脂质水平的评估。
J Pharm Biomed Anal. 2022 Nov 30;221:114990. doi: 10.1016/j.jpba.2022.114990. Epub 2022 Aug 8.
5
Lipidomic differentiation of Graves' ophthalmopathy in plasma and urine from Graves' disease patients.从 Graves 病患者的血浆和尿液中进行脂质组学区分 Graves 眼病。
Anal Bioanal Chem. 2018 Nov;410(27):7121-7133. doi: 10.1007/s00216-018-1313-2. Epub 2018 Aug 22.
6
Screening and identification of potential novel lipid biomarkers for non-small cell lung cancer using ultra-high performance liquid chromatography tandem mass spectrometry.采用超高效液相色谱-串联质谱法筛选和鉴定非小细胞肺癌潜在的新型脂质生物标志物。
Anat Rec (Hoboken). 2022 May;305(5):1087-1099. doi: 10.1002/ar.24725. Epub 2021 Aug 23.
7
Serum lipidomic biomarkers for non-small cell lung cancer in nonsmoking female patients.非吸烟女性非小细胞肺癌的血清脂质组学生物标志物。
J Pharm Biomed Anal. 2020 Jun 5;185:113220. doi: 10.1016/j.jpba.2020.113220. Epub 2020 Feb 29.
8
High-throughput and rapid quantification of lipids by nanoflow UPLC-ESI-MS/MS: application to the hepatic lipids of rabbits with nonalcoholic fatty liver disease.通过纳流超高效液相色谱-电喷雾串联质谱法对脂质进行高通量快速定量：在非酒精性脂肪性肝病兔肝脏脂质中的应用
Anal Bioanal Chem. 2016 Jul;408(18):4975-85. doi: 10.1007/s00216-016-9592-y. Epub 2016 May 13.
9
Changes in serum amino acid levels in non-small cell lung cancer: a case-control study in Chinese population.血清氨基酸水平在非小细胞肺癌中的变化：中国人群的病例对照研究。
PeerJ. 2022 Apr 20;10:e13272. doi: 10.7717/peerj.13272. eCollection 2022.
10
Aging-related lipidomic changes in mouse serum, kidney, and heart by nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry.纳米流超高效液相色谱-串联质谱法研究小鼠血清、肾脏和心脏中与衰老相关的脂质组变化。
J Chromatogr A. 2020 May 10;1618:460849. doi: 10.1016/j.chroma.2020.460849. Epub 2020 Jan 3.

引用本文的文献

1
Sphingolipid metabolism dysregulation: A cause for lung cancer development, progression, and resistance to therapies.鞘脂代谢失调：肺癌发生、发展及治疗耐药的一个原因。
Chin Med J Pulm Crit Care Med. 2025 Jun 13;3(2):88-96. doi: 10.1016/j.pccm.2025.05.002. eCollection 2025 Jun.
2
Unraveling the role of blood cell perturbation responses in lung cancer by Mendelian randomization.通过孟德尔随机化法揭示血细胞扰动反应在肺癌中的作用
Discov Oncol. 2025 Jun 15;16(1):1111. doi: 10.1007/s12672-025-02821-8.
3
Associations between lipids and lung cancer subtypes.

本文引用的文献

1
The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment.丝氨酸代谢在肺癌中的作用：从肿瘤发生到肿瘤治疗
Front Genet. 2023 Jan 9;13:1084609. doi: 10.3389/fgene.2022.1084609. eCollection 2022.
2
Anti-inflammatory and anti-viral actions of anionic pulmonary surfactant phospholipids.阴离子肺表面活性剂磷脂的抗炎和抗病毒作用。
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jun;1867(6):159139. doi: 10.1016/j.bbalip.2022.159139. Epub 2022 Feb 28.
3
Reprogramming of Lipid Metabolism in Lung Cancer: An Overview with Focus on EGFR-Mutated Non-Small Cell Lung Cancer.
脂质与肺癌亚型之间的关联。
Discov Oncol. 2025 May 2;16(1):656. doi: 10.1007/s12672-025-02450-1.
4
PinX1 plays multifaceted roles in human cancers: a review and perspectives.PinX1 在人类癌症中发挥多方面作用：综述与展望。
Mol Biol Rep. 2024 Nov 17;51(1):1163. doi: 10.1007/s11033-024-10082-x.
肺癌中脂质代谢的重编程：以 EGFR 突变型非小细胞肺癌为重点的概述。
Cells. 2022 Jan 25;11(3):413. doi: 10.3390/cells11030413.
4
Optimisation of saliva volumes for lipidomic analysis by nanoflow ultrahigh performance liquid chromatography-tandem mass spectrometry.通过纳流超高效液相色谱-串联质谱法优化脂质组学分析中的唾液量。
Anal Chim Acta. 2022 Feb 8;1193:339318. doi: 10.1016/j.aca.2021.339318. Epub 2021 Nov 23.
5
Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues.脂质组学和代谢组学分析揭示了非小细胞肺癌组织生化途径的变化。
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Feb;1867(2):159082. doi: 10.1016/j.bbalip.2021.159082. Epub 2021 Nov 15.
6
Dysregulation of cholesterol homeostasis in human lung cancer tissue and tumour-associated macrophages.人肺癌组织和肿瘤相关巨噬细胞中胆固醇动态平衡的失调。
EBioMedicine. 2021 Oct;72:103578. doi: 10.1016/j.ebiom.2021.103578. Epub 2021 Sep 25.
7
Lung cancer.肺癌。
Lancet. 2021 Aug 7;398(10299):535-554. doi: 10.1016/S0140-6736(21)00312-3. Epub 2021 Jul 21.
8
Salivary microRNAs show potential as biomarkers for early diagnosis of malignant pleural effusion.唾液微小RNA有望成为恶性胸腔积液早期诊断的生物标志物。
Transl Lung Cancer Res. 2020 Aug;9(4):1247-1257. doi: 10.21037/tlcr-19-530.
9
Metabolome of canine and human saliva: a non-targeted metabolomics study.犬和人唾液代谢组学研究：一种非靶向代谢组学研究。
Metabolomics. 2020 Aug 25;16(9):90. doi: 10.1007/s11306-020-01711-0.
10
Lipid alterations and subtyping maker discovery of lung cancer based on nontargeted tissue lipidomics using liquid chromatography-mass spectrometry.基于非靶向组织脂质组学的液相色谱-质谱联用技术对肺癌的脂质改变和亚型标志物的发现。
J Pharm Biomed Anal. 2020 Oct 25;190:113520. doi: 10.1016/j.jpba.2020.113520. Epub 2020 Aug 4.