Nakano Toshiaki
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
J Atheroscler Thromb. 2025 Feb 1;32(2):111-119. doi: 10.5551/jat.RV22030. Epub 2024 Nov 16.
Patients with chronic kidney disease (CKD) have a high incidence of atherosclerotic diseases, such as ischemic heart disease, cerebrovascular disease, and peripheral arterial disease. To prevent the incidence of atherosclerotic cardiovascular disease in patients with CKD, the pathology of arteriosclerosis should be determined. Vascular calcification is a characteristic of arteriosclerosis in patients with CKD. Recent studies have reported that coronary artery calcification is associated with acute coronary syndromes. CKD is frequently associated with heart failure. Furthermore, recent evidence suggests that coronary artery calcification affects asymptomatic myocardial ischemia. Hyperphosphatemia and calciprotein particles may be involved in the pathology of vascular calcification. Controlling the progression of vascular calcification and classical atherosclerotic risk factors is important to prevent the occurrence of atherosclerotic diseases in CKD.
慢性肾脏病（CKD）患者发生动脉粥样硬化性疾病的几率很高，如缺血性心脏病、脑血管疾病和外周动脉疾病。为预防CKD患者发生动脉粥样硬化性心血管疾病，应明确动脉硬化的病理情况。血管钙化是CKD患者动脉硬化的一个特征。最近的研究报告称，冠状动脉钙化与急性冠状动脉综合征有关。CKD常与心力衰竭相关。此外，最近的证据表明，冠状动脉钙化会影响无症状心肌缺血。高磷血症和钙蛋白颗粒可能参与血管钙化的病理过程。控制血管钙化的进展和经典的动脉粥样硬化危险因素对于预防CKD患者发生动脉粥样硬化性疾病很重要。
