使用污水流行病学、长距离 PCR 和病原体测序技术对 2019 年 10 月至 2020 年 3 月美国亚利桑那州的腺病毒 41 进行多样性分析。
Adenovirus 41 diversity in Arizona (USA) using wastewater-based epidemiology, long-range PCR, and pathogen sequencing between October 2019 and March 2020.
机构信息
Biodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, AZ85287, USA.
College of Health Solutions, Arizona State University, Tempe, AZ, USA.
出版信息
Epidemiol Infect. 2024 Nov 18;152:e142. doi: 10.1017/S095026882400133X.
By coupling long-range polymerase chain reaction, wastewater-based epidemiology, and pathogen sequencing, we show that adenovirus type 41 hexon-sequence lineages, described in children with hepatitis of unknown origin in the United States in 2021, were already circulating within the country in 2019. We also observed other lineages in the wastewater, whose complete genomes have yet to be documented from clinical samples.
通过结合长距离聚合酶链反应、基于废水的流行病学和病原体测序，我们表明，2021 年在美国不明原因肝炎儿童中描述的腺病毒 41 型六邻体序列谱系，早在 2019 年就在该国流行。我们还在废水中观察到其他谱系，其完整基因组尚未从临床样本中记录。
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