食物特异性 IgG 抗体对偏头痛及其共病的影响。
The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities.
机构信息
Health Center of Screening and Prevention of Diseases, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Department of Neurology, Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
出版信息
Immun Inflamm Dis. 2024 Nov;12(11):e70056. doi: 10.1002/iid3.70056.
OBJECTIVE
To investigate the differences in headache and comorbidity symptoms between migraine patients with negative and positive food specific IgG antibodies, and explore the correlation between these symptoms with food specific IgG antibodies.
METHODS
A total of 129 migraine patients were enrolled. Seven questionnaires were used to gather information regarding the symptoms of migraine, gastrointestinal, depression, anxiety, and sleep. Serum specific IgG antibodies against 14 kinds of food were detected using enzyme-linked immunosorbent assays.
RESULTS
Patients with migraine diagnosis who had positive food specific IgG antibodies had significantly worse headaches, gastrointestinal and anxiety symptoms, compared to the patients with negative IgG antibodies. Patients with more IgG positive foods and higher total positive IgG concentration generally had worse migraine conditions, anxiety, depression, and gastrointestinal symptoms.
CONCLUSION
The effect of food specific IgG antibodies on severity of migraine and its comorbidities were antibody-quantity and IgG-concentration dependent. Future studies are warranted to explore the mechanism underlying such relationship.
目的
研究食物特异性 IgG 抗体阴性和阳性的偏头痛患者头痛和共病症状的差异，并探讨这些症状与食物特异性 IgG 抗体之间的相关性。
方法
共纳入 129 例偏头痛患者。使用 7 份问卷收集偏头痛、胃肠道、抑郁、焦虑和睡眠症状的信息。采用酶联免疫吸附试验检测血清中 14 种食物的特异性 IgG 抗体。
结果
与 IgG 阴性的患者相比，食物特异性 IgG 抗体阳性的偏头痛患者头痛、胃肠道和焦虑症状明显更严重。具有更多 IgG 阳性食物和更高总阳性 IgG 浓度的患者一般具有更严重的偏头痛、焦虑、抑郁和胃肠道症状。
结论
食物特异性 IgG 抗体对偏头痛严重程度及其合并症的影响与抗体数量和 IgG 浓度有关。需要进一步的研究来探讨这种关系的潜在机制。
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