Khorsha Faezeh, Mirzababaei Atieh, Ghodoosi Nasim, Togha Mansoureh, Yekaninejad Mir Saeed, Askarpour Moein, Mirzaei Khadijeh
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Curr J Neurol. 2020 Apr 3;19(2):67-75. doi: 10.18502/cjn.v19i2.4943.
Migraine is a neurologic disorder. Although, based on previous evidence, migraine is related with inflammation and oxidative stress, its relationship with the inflammatory potential of the diet is still unknown. Thus, the aim of this study was to show the correlation between Dietary Inflammatory Index (DII) and severity and duration of migraine headache. In this cross-sectional study, 266 women who suffered from migraine, were included. Demographic and anthropometric data were collected form all participants. 147-item semiquantitative food frequency questionnaire (FFQ) was collected to assess dietary intake and consequently, DII scores were calculated. Migraine Disability Assessment (MIDAS) questionnaire, Visual Analog Scale (VAS), and a 30-day headache diary were also completed by each participant. The DII score ranged between -4.22 and 5.19 and its median [interquartile range (IQR)] was 0.003 (-1.48-1.55). There was no meaningful association between age, occupation, physical activity (PA), weight, height, Body Mass Index (BMI), waist circumference (WC), hip circumference, waist-to-hip ratio (WHR) and DII score classifications (P > 0.050). Subjects with more than 20 days of headache had higher DII score compared to those with less than 10 days per month [odds ratio (OR) = 1.60, 95% confidence interval (CI) = 1.12-2.08, P = 0.001]. There was no association between DII and migraine severity (VAS and MIDAS) in the crude and adjusted model of logistic regression. Although there was a significant association between headache duration and DII (P = 0.020), this relationship was not meaningful after adjusting for age, PA, BMI, and job status (OR = 0.53, 95% CI = 0.28-1.00, P = 0.052). The present study showed a direct association between headache frequency and DII. Nevertheless, any relationship was not found between headache duration or migraine severity and DII score. Future large and prospective studies are needed to explore the effect of inflammatory potential of diet in migraine characteristics.
偏头痛是一种神经系统疾病。尽管根据以往证据，偏头痛与炎症和氧化应激有关，但其与饮食炎症潜能之间的关系仍不清楚。因此，本研究的目的是揭示饮食炎症指数（DII）与偏头痛严重程度及持续时间之间的相关性。在这项横断面研究中，纳入了266名患有偏头痛的女性。收集了所有参与者的人口统计学和人体测量数据。采用147项半定量食物频率问卷（FFQ）评估饮食摄入量，进而计算DII得分。每位参与者还完成了偏头痛残疾评估（MIDAS）问卷、视觉模拟量表（VAS）以及一份为期30天的头痛日记。DII得分在-4.22至5.19之间，其中位数[四分位数间距（IQR）]为0.003（-1.48 - 1.55）。年龄、职业、身体活动（PA）、体重、身高、体重指数（BMI）、腰围（WC）、臀围、腰臀比（WHR）与DII得分分类之间无显著关联（P > 0.050）。每月头痛超过20天的受试者的DII得分高于每月头痛少于10天的受试者[比值比（OR） = 1.60，95%置信区间（CI） = 1.12 - 2.08，P = 0.001]。在逻辑回归的原始模型和校正模型中，DII与偏头痛严重程度（VAS和MIDAS）之间无关联。尽管头痛持续时间与DII之间存在显著关联（P = 0.020），但在校正年龄、PA、BMI和工作状态后，这种关系无统计学意义（OR = 0.53，95% CI = 0.28 - 1.00，P = 0.052）。本研究显示头痛频率与DII之间存在直接关联。然而，未发现头痛持续时间或偏头痛严重程度与DII得分之间存在任何关系。未来需要开展大规模前瞻性研究，以探索饮食炎症潜能对偏头痛特征的影响。
