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乔治·戈莫里对糖尿病研究的贡献及……的起源

George Gomori's Contributions to Diabetes Research and the Origins of the .

作者信息

Baskin Denis G

机构信息

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington (DGB).

出版信息

J Histochem Cytochem. 2024 Nov-Dec;72(11-12):729-731. doi: 10.1369/00221554241300370. Epub 2024 Nov 18.

Abstract

Over a period of almost 30 years, Gomori was one of the most prolific and productive investigators in the emerging field of enzyme histochemistry and was recognized by his peers as a pioneer in developing methods for the histochemical demonstration of hydrolytic enzyme activity, most notably phosphatases, esterases, and lipases. Gomori also made important contributions to diabetes research by developing histological techniques that reliably stained the insulin-secreting B cell of the pancreatic islets of Langerhans. Gomori's aldehyde fuchsin staining method was standard for pathological and physiological studies on islet B cells in relation to diabetes and obesity until insulin antibodies became widely available for immunohistochemical identification of B cells. Gomori was a founding member of The Histochemical Society in 1950. When the HCS established the in 1953, Gomori served as one of the first Associate Editors. He also served as President of The Histochemical Society.

摘要

在近30年的时间里,戈莫里是新兴的酶组织化学领域最多产、最有成果的研究者之一,被同行公认为是开发水解酶活性组织化学显示方法的先驱,最著名的是磷酸酶、酯酶和脂肪酶。戈莫里还通过开发能可靠地对胰岛中分泌胰岛素的β细胞进行染色的组织学技术,为糖尿病研究做出了重要贡献。在胰岛素抗体广泛用于β细胞的免疫组织化学鉴定之前,戈莫里的醛复红染色法一直是胰岛β细胞与糖尿病和肥胖相关的病理和生理研究的标准方法。戈莫里是1950年组织化学学会的创始成员之一。1953年组织化学学会设立该杂志时,戈莫里担任首批副主编之一。他还担任过组织化学学会会长。

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