《生物化学论文集》关于 AMPK 和 AMPK 相关激酶的特刊。
A special issue of Essays in Biochemistry on AMPK and AMPK-related kinases.
机构信息
School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.
MRC Laboratory of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0HS, U.K.
出版信息
Essays Biochem. 2024 Nov 18;68(3):269-271. doi: 10.1042/EBC20240038.
In eukaryotic cells, AMP-activated protein kinase (AMPK) plays a central role in responding to nutrient limitation by switching-off ATP-consuming (anabolic) pathways and switching-on ATP generating (catabolic) pathways. Over the last 30 years or so, a considerable body of research has been carried out that has provided us with a wealth of knowledge regarding the regulation and role of AMPK. Despite this, there is still much to learn about AMPK and the field remains highly active, with many groups around the world continuing to explore new roles for AMPK, providing insight into its biological function. This review series was inspired by recent AMPK-focused meetings in Scotland (2022) and Australia (2023) and draws on some of the research presented at those meetings.
在真核细胞中，腺苷酸活化蛋白激酶（AMPK）在响应营养限制方面起着核心作用，它通过关闭 ATP 消耗（合成代谢）途径和开启 ATP 生成（分解代谢）途径来实现这一点。在过去的 30 年左右的时间里，已经进行了大量的研究，为我们提供了关于 AMPK 的调节和作用的丰富知识。尽管如此，关于 AMPK 仍有许多需要了解的地方，该领域仍然非常活跃，世界各地的许多研究小组继续探索 AMPK 的新作用，为其生物学功能提供了新的见解。本综述系列受到 2022 年在苏格兰和 2023 年在澳大利亚举行的 AMPK 专题会议的启发，并借鉴了这些会议上提出的部分研究成果。
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