Göransson Olga, Kopietz Franziska, Rider Mark H
Lund University, Department of Experimental Medical Science, BMC, 221 84 Lund, Sweden.
Lund University, Department of Experimental Medical Science, BMC, 221 84 Lund, Sweden.
Trends Endocrinol Metab. 2023 Nov;34(11):704-717. doi: 10.1016/j.tem.2023.08.011. Epub 2023 Sep 4.
White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when treating type 2 diabetes with pharmacological pan-AMPK activators.
白色脂肪组织（WAT）通过储存脂肪并在需要时动员三酰甘油，在全身代谢整合中发挥重要作用。释放出的游离脂肪酸随后可被其他组织氧化以提供ATP。AMP激活的蛋白激酶（AMPK）是代谢途径的关键调节因子，可被新一代直接的小分子激活剂作用。白色脂肪组织中AMPK的激活会抑制胰岛素刺激的脂肪生成，在某些情况下还会抑制胰岛素刺激的葡萄糖摄取，但AMPK诱导的对β-肾上腺素能激动剂刺激的脂肪分解的抑制作用可能需要在体内重新评估。在用药物性泛AMPK激活剂治疗2型糖尿病时，AMPK激活对白色脂肪组织基础代谢缺乏显著影响可能是有利的。
