Gil Eliza, Hatcher James, Saram Sophia de, Guy Rebecca L, Lamagni Theresa, Brown Jeremy S
UCL Respiratory, Division of Medicine, University College London, London, WC1E 6JF, UK.
Clinical Research Department, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Future Microbiol. 2025 Feb;20(2):163-177. doi: 10.1080/17460913.2024.2423524. Epub 2024 Nov 18.
is an oral commensal organism belonging to the group (SAG). causes periodontitis as well as invasive, pyogenic infection of the central nervous system, pleural space or liver. Compared with other SAG organisms, has a higher mortality as well as a predilection for intracranial infection, suggesting it is likely to possess virulence factors that mediate specific interactions with the host resulting in bacteria reaching the brain. The mechanisms involved are not well described. Intracranial suppuration (ICS) due to infection can manifest as an abscess within the brain parenchyma, or a collection of pus (empyema) in the sub- or extra-dural space. These infections necessitate neurosurgery and prolonged antibiotic treatment and are associated with a considerable burden of morbidity and mortality. The incidence of ICS is increasing in several settings, with SAG species accounting for an increasing proportion of cases. There is a paucity of published literature regarding pathogenesis as well as few published genomes, hampering molecular epidemiological research. This perspective evaluates what is known about the clinical features and pathogenesis of ICS due to and explores hypothetical explanations why the incidence of these infections may be increasing.
是一种属于龈下菌丛组（SAG）的口腔共生菌。可导致牙周炎以及中枢神经系统、胸腔或肝脏的侵袭性化脓性感染。与其他SAG菌相比，其死亡率更高，且更易发生颅内感染，这表明它可能拥有介导与宿主特异性相互作用的毒力因子，从而使细菌进入大脑。其中涉及的机制尚未得到充分描述。由感染引起的颅内化脓（ICS）可表现为脑实质内的脓肿，或硬膜下或硬膜外间隙的脓液积聚（积脓）。这些感染需要进行神经外科手术和长期抗生素治疗，且与相当大的发病率和死亡率负担相关。在多种情况下，ICS的发病率都在上升，SAG菌种在病例中所占比例也越来越大。关于其发病机制的已发表文献很少，已发表的基因组也很少，这阻碍了分子流行病学研究。本观点评估了关于因感染导致的ICS的临床特征和发病机制的已知情况，并探讨了这些感染发病率可能上升的假设性解释。
