Zhou Huiru, Zhang Liqin
Second Intensive Care Unit, Gansu Provincial Hospital, China.
J Int Med Res. 2025 Aug;53(8):3000605251363093. doi: 10.1177/03000605251363093. Epub 2025 Aug 11.
Infectious diseases of the central nervous system are commonly characterized by delayed diagnosis due to the diversity of pathogens, subtle clinical symptoms, and nonspecific early imaging findings. These diseases are associated with high morbidity and mortality rates. This report presents a rare case of intracranial mixed infection caused by co-infection with and torque teno virus. This report involves a retrospective analysis of the clinical features, laboratory investigations, and treatment outcomes of intracranial infection, along with diagnostic and therapeutic strategies for such rare mixed infections. The results demonstrated that cerebrospinal fluid metagenomic sequencing plays a crucial role in the microbiological diagnosis of intracranial mixed infection. This report describes the case of a man in his late 30s in whom and torque teno virus were simultaneously detected in the cerebrospinal fluid. The infection exhibited rapid progression and high aggressiveness, significantly increasing the risk of mortality. This study emphasizes the invasive clinical course of this infection. Despite active and intensive treatment, the patient ultimately succumbed to the illness. It remains unclear whether torque teno virus infection plays a direct role in the pathogenesis or contributes to the severity of the intracranial mixed infection. This case highlights the importance of multidisciplinary collaboration in the diagnosis and treatment of complex intracranial infections, providing clinicians with a novel approach for the differential diagnosis of mixed infections and increasing the clinical awareness and understanding of such rare mixed infections involving the central nervous system.
中枢神经系统感染性疾病通常具有诊断延迟的特点，这是由于病原体的多样性、临床症状不明显以及早期影像学表现不具有特异性。这些疾病的发病率和死亡率都很高。本报告介绍了一例由与Torque teno病毒共同感染引起的颅内混合感染罕见病例。本报告涉及对颅内感染的临床特征、实验室检查和治疗结果进行回顾性分析，以及针对此类罕见混合感染的诊断和治疗策略。结果表明，脑脊液宏基因组测序在颅内混合感染的微生物学诊断中起着关键作用。本报告描述了一名30多岁男性的病例，其脑脊液中同时检测到了与Torque teno病毒。该感染表现出快速进展和高侵袭性，显著增加了死亡风险。本研究强调了这种感染的侵袭性临床病程。尽管进行了积极和强化治疗，患者最终还是因病死亡。目前尚不清楚Torque teno病毒感染在发病机制中是否起直接作用或是否加剧了颅内混合感染的严重程度。该病例突出了多学科协作在复杂颅内感染诊断和治疗中的重要性，为临床医生提供了一种鉴别混合感染的新方法，并提高了对这种涉及中枢神经系统的罕见混合感染的临床认识和理解。
