Exploring the Global Legacy of Professor Calayampudi Radhakrishna Rao: A Review of His Life and Biostatistical Contributions.

This review article explores the seminal contributions of Professor C.R. Rao, one of the most influential statisticians of the 20th century, whose work has profoundly impacted statistical theory and its applications in various fields, particularly in medical statistics. This article discusses the theoretical foundations laid by Rao, including the Rao-Blackwell theorem, Cramer-Rao lower bound, and orthogonal arrays, and examines how these concepts have been applied to enhance medical research, from epidemiological studies to clinical trials. The article highlights the enduring relevance of Rao's work in improving the precision and efficiency of statistical methods used in medical research. The article also outlines his significant achievements and awards, underscoring his global statistical influence.