5-羟色胺对大鼠胃分泌功能的抑制作用。
The inhibitory action of 5-hydroxytryptamine on gastric secretory function in rats.
作者信息
Cho C H, Ogle C W
出版信息
Br J Pharmacol. 1986 Feb;87(2):371-7. doi: 10.1111/j.1476-5381.1986.tb10826.x.
The inhibitory action of 5-hydroxytryptamine (5-HT) on gastric function was studied in vagotomized rats. 5-HT (0.6, 1 or 5 mgkg-1, s.c.) dose-dependently reduced gastric acid secretion evoked by histamine, pentagastrin or methacholine. Pepsin secretion induced by pentagastrin or methacholine was also depressed by 5-HT. Basal secretion of both acid and pepsin was not significantly affected by any of the three 5-HT doses. Indomethacin pretreatment, which significantly decreased gastric mucosal prostaglandin E2 content, did not modify the inhibitory effects of 5-HT on histamine-induced acid secretion, nor did phentolamine or propranolol. This study suggests that 5-HT inhibits gastric secretory function through mechanisms other than by sympathetic influence or increased prostaglandin synthesis. The inhibitory action appears not to be vagus-dependent. Other mechanisms of action are discussed.
在迷走神经切断的大鼠中研究了5-羟色胺（5-HT）对胃功能的抑制作用。5-HT（0.6、1或5mgkg-1，皮下注射）剂量依赖性地减少组胺、五肽胃泌素或乙酰甲胆碱引起的胃酸分泌。五肽胃泌素或乙酰甲胆碱诱导的胃蛋白酶分泌也被5-HT抑制。三种5-HT剂量中的任何一种对胃酸和胃蛋白酶的基础分泌均无显著影响。消炎痛预处理可显著降低胃黏膜前列腺素E2含量，但并未改变5-HT对组胺诱导的胃酸分泌的抑制作用，酚妥拉明或普萘洛尔也未改变这种作用。本研究提示，5-HT通过交感神经影响或增加前列腺素合成以外的机制抑制胃分泌功能。这种抑制作用似乎不依赖于迷走神经。还讨论了其他作用机制。
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