前列腺素E2对大鼠胃分泌的中枢抑制作用。

Central inhibitory action of prostaglandin E2 on gastric secretion in the rat.

作者信息

Puurunen J

出版信息

Eur J Pharmacol. 1983 Jul 22;91(2-3):245-9. doi: 10.1016/0014-2999(83)90472-7.

Abstract

The central nervous system action of prostaglandin E2 (PGE2) on gastric secretion was studied in conscious pylorus-ligated rats. It was found that 1-10 micrograms of PGE2 given i.c.v. reduced the gastric output of acid, pepsin and fluid in a dose-dependent manner whereas 30-300 micrograms was required for inhibition when given subcutaneously. Given i.c.v. 400 micrograms of indomethacin, a potent inhibitor of prostaglandin biosynthesis, enhanced gastric secretion but not when given intramuscularly. It is concluded that PGE2 has a central inhibitory action on gastric secretion in conscious rats. In addition, the possibility that PGE2 may be involved as inhibitory modulator in the central control of gastric secretion warrants further attention.

摘要

在清醒的幽门结扎大鼠中研究了前列腺素E2（PGE2）对胃分泌的中枢神经系统作用。发现脑室内注射1 - 10微克PGE2可剂量依赖性地减少胃酸、胃蛋白酶和胃液的分泌量，而皮下注射时则需要30 - 300微克才能产生抑制作用。脑室内注射400微克吲哚美辛（一种前列腺素生物合成的强效抑制剂）可增强胃分泌，但肌肉注射时则无此作用。结论是PGE2对清醒大鼠的胃分泌具有中枢抑制作用。此外，PGE2可能作为抑制性调节因子参与胃分泌中枢控制的可能性值得进一步关注。